#Science: The Potential and the Challenges of Utilizing Social Media and Other Electronic Communication Platforms in Health Care.

Electronic communication is becoming increasingly popular worldwide, as evidenced by its widespread and rapidly growing use. In medicine, however, it remains a novel approach to reach out to patients. Yet, they have the potential for further improving current health care.

P450 oxidoreductase *28 (POR*28) and tacrolimus disposition in pediatric kidney transplant recipients--a pilot study.

Background: Both age and CYP3A5 genotype are important determinants of tacrolimus disposition in pediatric kidney transplant recipients. In a recent study in adults, POR*28 was associated with increased dosing requirements early after transplant of CYP3A5-expressing kidney transplant recipients. The authors aimed to evaluate the additional contribution of POR*28 to early tacrolimus disposition in pediatric kidney transplant recipients.

CYP3A4*22 and CYP3A combined genotypes both correlate with tacrolimus disposition in pediatric heart transplant recipients.

Background: Tacrolimus metabolism depends on CYP3A4 and CYP3A5. We aimed to determine the relationship between the CYP3A4*22 polymorphism and combined CYP3A genotypes with tacrolimus disposition in pediatric heart transplant recipients.

Methods: Sixty pediatric heart transplant recipients were included.

Prevalence of renal dysfunction in tacrolimus-treated pediatric transplant recipients: a systematic review.

Renal dysfunction after non-renal transplantation in adult tacrolimus-treated transplant patients is well documented. Little is known about its prevalence in children. Age-related changes in both disposition and effect of tacrolimus as well as renal function may preclude extrapolation of adult data to children.

Tacrolimus-induced nephrotoxicity and genetic variability: a review.

Background: Calcineurin inhibition (CNI) is the mainstay of immunosuppressant therapy for most solid organ transplant patients. High tacrolimus levels are related with acute nephrotoxicity, but the relationship with chronic toxicity is less clear. Variation in disposition of tacrolimus is associated with genetic variation in CYP3A5.

The effect of distant reiki on pain in women after elective Caesarean section: a double-blinded randomised controlled trial.

Introduction: Approximately 25% of all babies in North America are delivered via Caesarean section (C-section). Though a common surgical procedure, C-section recovery can be painful. Opioids, specifically codeine, are commonly used to ease pain; however, its active metabolite, morphine, passes into breast milk, and may produce unwanted side effects in neonates; therefore, alternatives to opioids are being sought.

Age and CYP3A5 genotype affect tacrolimus dosing requirements after transplant in pediatric heart recipients.

Background: Tacrolimus is one of the commonly used immunosuppressive drugs for pediatric heart transplants. Large variation exists in pharmacokinetics during the direct post-transplant period, resulting in an increased risk of adverse events. Limited data are available on the interaction of age, CYP3A5 and ABCB1 genotype, and disease severity on the variation in disposition and outcome in pediatric heart transplant recipients.

CYP2D6 polymorphisms and codeine analgesia in postpartum pain management: a pilot study.

Background: Codeine, a common opiate prescribed for pain postcesarean section (c-section), is biotransformed by the highly polymorphic Cytochrome P450 enzyme 2D6 (CYP2D6). Ultrarapid metabolizers (UMs), individuals with multiple active copies of CYP2D6, can biotranform up to 50% more codeine into morphine than normal individuals can. In contrast, poor metabolizers (PMs), individuals who have no active CYP2D6 genes, convert almost no codeine into morphine and as a result may take multiple doses of codeine without attaining analgesia.

Acute liver failure after recommended doses of acetaminophen in patients with myopathies.

Objective: To determine the likelihood that recommended doses of acetaminophen are associated with acute liver failure in patients with myopathies.

Design: Retrospective analysis.

Setting: Level III pediatric intensive care unit.

A systematic review of the therapeutic effects of Reiki.

Introduction: Reiki is an ancient form of Japanese healing. While this healing method is widely used for a variety of psychologic and physical symptoms, evidence of its effectiveness is scarce and conflicting. The purpose of this systematic review was to try to evaluate whether Reiki produces a significant treatment effect.

Probability of rash related to gabapentin therapy in a child.

Objective: To describe a child who developed a skin reaction during gabapentin therapy and discuss how we evaluated the probability of an adverse drug reaction.

Case Summary: An 8-year-old boy with a neurodegenerative disease of unknown origin and an epilepsy disorder developed an urticarial rash and irritability 10 and 4 days, respectively, after the start of gabapentin 20 mg/kg 3 times a day for epilepsy control. Otherwise, the child was well; no changes in other medication or diet had recently been made.

Does light drinking during pregnancy improve pregnancy outcome? A critical commentary.

A recent study published from the University College London suggests that children of women who were light drinkers during pregnancy demonstrate better cognitive outcome at three years of age when compared to children of abstinent women based on data from the UK Millennium Cohort Study. Unfortunately, methodological pitfalls and limited external validity of the results presented make conclusions very tenuous. This paper was widely quoted by the media, sometimes concluding that drinking is beneficial.