Importance of revealing a rare case of breast cancer in a female to male transsexual after bilateral mastectomy.

The incidence of breast carcinoma following prophylactic mastectomy is probably less than 2%. We present a 43-year-old female to male transsexual who developed breast cancer 1 year after bilateral nipple- sparing subcutaneous mastectomy as part of female to male gender reassignment surgery. In addition to gender reassignment surgery, total abdominal hysterectomy with bilateral salpingo-oophorectomy (to avoid the patient from entering menopause and to eliminate any subsequent risk of iatrogenic endometrial carcinoma), colpocleisys, metoidioplasty, phalloplasty, urethroplasty together with scrotoplasty/placement of testicular prosthesis and perineoplasty were also performed.

[TRAb determination in newly detected patients with hyperthyroidism and their prognostic importance].

Introduction: In more than 50 years since the first demonstration of the immune basis for thyroiditis was done, the autoimmune disease has been identified as a major cause of disfunction of all endocrine organs. Identification of the antithyroid with the radioreceptor assay is widespread in clinical use for differential diagnosis of other thyroid disorders manifesting with the hyperthyroidism.

Material And Methods: Our study included 44 patients with new onset Graves disease which was primarily verified according to the objective status of the patients (signs of hyperthyroidism), biochemical parameters (which included thyroid hormones) and detection of the TRAb (TSAb- thyreotropin-stimulating antibodies) at the beginning of diagnosis and in the first, second and after the third month since the introduction of antithyroid therapy (propiltiouracil).

[Efficient way in early detection of malignant skin tumors by applying epiluminescence microscopy in skin screening].

Screening is the identification of a preclinical disease by a relatively simple test. It is usually regarded as public health policy that is applied to population. The aim is to identify disease not recognized by the health services and the term preclinical refers rather to such an unrecognized disease than to clinical detectability or recognition.

Evaluation of ribavirin efficacy and tolerance in subjects with chronic hepatitis C virus infection.

Background: Reports by hepatologists indicated that anti-HCV antibodies might be detected in 71% to 84% of cases of post-transfusion hepatitis and in up to 50% of cases of sporadic non-A non-B hepatitis. Anti-HCV antibodies were detected in 0.05-1% of blood donors with normal alanine transaminase (ALT) levels and negative anti-HBc screening.