Hypercalcemia in Necrobiotic Xanthogranuloma: First Reported Case and Insight Into Treatment.

Necrobiotic xanthogranuloma (NXG) is a rare systemic and progressive granulomatous disease first described in 1980. Given no established first-line therapy, treatment focuses on the control of skin lesions and associated complications. Despite it being a granulomatous disease, NXG has not been associated with hypercalcemia.

Perioperative management of a patient with a nonresectable pheochromocytoma.

Objective: To describe the clinical course of a patient with a nonresectable pheochromocytoma during urgent hip surgery.

Methods: To describe the clinical management and postoperative outcome of the patient and review the relevant literature.

Results: An 85-year-old male with a nonresectable pheochromocytoma required urgent hip surgery following a traumatic hip fracture.

Laboratory measurement of growth hormone.

Growth hormone (GH) measurements are complicated by the heterogeneous nature of GH, as well as by the presence of the GH binding protein in plasma. Several isoforms of GH exist, and specific assays for each are currently either unavailable, impractical, or not clinically indicated. Bioassays include the in vivo assays based on rat weight gain, tibial line widening, or IGF-I generation.