Publications by authors named "Violaine Regard"
Adrenal cortex and gonads represent the two major steroidogenic organs in mammals. Both tissues are considered to share a common developmental origin characterized by the expression of Nr5a1/Sf1. The precise origin of adrenogonadal progenitors and the processes driving differentiation toward the adrenal or gonadal fate remain, however, elusive.
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- Gonadal sex determination is a complex process that involves understanding the different cell lineages in developing testis and ovary, which is still not fully understood.
- This study focuses on a newly identified population of supporting-like cells (SLCs) in developing mouse gonads, which is the first somatic cell lineage to be specified early in development.
- The research reveals that SLCs start to show sex differences around E12.5, ultimately helping to form structures like the rete testis and rete ovarii, with WNT4 playing a key regulatory role in their development.