Publications by authors named "Viola Close"
Aberrant Notch signaling plays a pivotal role in T-cell acute lymphoblastic leukemia (T-ALL) and chronic lymphocytic leukemia (CLL). Amplitude and duration of the Notch response is controlled by ubiquitin-dependent proteasomal degradation of the Notch1 intracellular domain (NICD1), a hallmark of the leukemogenic process. Here, we show that HDAC3 controls NICD1 acetylation levels directly affecting NICD1 protein stability.
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- Chronic lymphocytic leukemia (CLL) cells need help from other normal bone marrow cells to survive, and when they don't get it, they start to die.
- Researchers found that when CLL cells are protected by these normal cells, they behave differently, especially in terms of energy production and reactions to low oxygen levels.
- Some drugs, like emetine, were shown to help fight CLL by disrupting this support system and improving survival in test models.
Chronic lymphocytic leukemia (CLL) is known for its strong dependency on the tumor microenvironment. We found progranulin (GRN), a protein that has been linked to inflammation and cancer, to be upregulated in the serum of CLL patients compared to healthy controls, and increased GRN levels to be associated with an increased hazard for disease progression and death. This raised the question of whether GRN is a functional driver of CLL.
View Article and Find Full Text PDFis mutated in 10% of chronic lymphocytic leukemia (CLL) patients and is associated with poor outcome. However, NOTCH1 activation is identified in approximately one-half of CLL cases even in the absence of mutations. Hence, there appear to be additional factors responsible for the impairment of NOTCH1 degradation.
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