Widening the Prostacyclin Paradigm: Tissue Fibroblasts Are a Critical Site of Production and Antithrombotic Protection.

Background: Prostacyclin is a fundamental signaling pathway traditionally associated with the cardiovascular system and protection against thrombosis but which also has regulatory functions in fibrosis, proliferation, and immunity. Prevailing dogma states that prostacyclin is principally derived from vascular endothelium, although it is known that other cells can also synthesize it. However, the role of nonendothelial sources in prostacyclin production has not been systematically evaluated resulting in an underappreciation of their importance relative to better characterized endothelial sources.

Incidence of socially significant infectious diseases (HIV, TB and HIV/TB coinfection) in the Arctic regions of Russia).

The study is aimed to evaluate the HIV, TB, and HIV/TB coinfection incidence per 100,000 population/year in Russian Arctic, based on official statistical data. The epidemics' incidence in Russian Arctic is uneven. The highest HIV incidence in 2019 was registered in Krasnoyarsk region (94,6), and the highest TB incidence in ChAD (136,1).

Crystal structure and Hirshfeld surface analysis of ()-3-hy-droxy-2-{[(3a,6,7a)-2-(4-methyl-phenyl-sulfon-yl)-2,3,3a,6,7,7a-hexa-hydro-3a,6-ep-oxy-1-isoindol-6-yl]meth-yl}isoindolin-1-one.

The title compound, CHNOS, crystallizes with two independent mol-ecules ( and ) in the asymmetric unit. In the central ring systems of both mol-ecules, the tetra-hydro-furan rings adopt envelope conformations, the pyrrolidine rings adopt a twisted-envelope conformation and the six-membered ring is in a boat conformation. In mol-ecules and , the nine-membered groups attached to the central ring system are essentially planar (r.

Application of New Efficient Hoveyda-Grubbs Catalysts Comprising an N→Ru Coordinate Bond in a Six-Membered Ring for the Synthesis of Natural Product-Like Cyclopenta[]furo[2,3-]pyrroles.

The ring rearrangement metathesis (RRM) of a - diastereomer mixture of methyl 3-allyl-3a,6-epoxyisoindole-7-carboxylates derived from cheap, accessible and renewable furan-based precursors in the presence of a new class of Hoveyda-Grubbs-type catalysts, comprising an N→Ru coordinate bond in a six-membered ring, results in the difficult-to-obtain natural product-like cyclopenta[]furo[2,3-]pyrroles. In this process, only one diastereomer with a -arrangement of the 3-allyl fragment relative to the 3a,6-epoxy bridge enters into the rearrangement, while the -isomers polymerize almost completely under the same conditions. The tested catalysts are active in the temperature range from 60 to 120 °C at a concentration of 0.

GENETIC DIVERSITY OF THE MYCOBACTERIUM TUBERCULOSIS ISOLATES IN THE REPUBLIC SAKHA (YAKUTIA), RUSSIA.

The population structure of the M. tuberculosis in Yakutia was estimated by the MIRU-VNTR method of 24 loci genotyping. 199 strains from 199 patients with pulmonary tuberculosis were tested.

[Effect of auto-road complex in the city of Surgut on air pollution and population health].

Currently, due to the increase in motorization, the problem of environmental pollution by emissions of objects of auto-road complex is becoming more and more important not only for cities, butfor dynamically developing regional cities. The negative impact is characterized by the increase of the morbidity rate of environmentally-dependent diseases, primarily respiratory diseases, neoplasms. This exposure is most pronounced near the motorways, at the gas station, and also spreads to residential areas, which requires the optimization of protective and preventive measures.

[Providing safe environment for health of population living near aluminium industry enterprises].

Based on studies of environmental objects and of children's health, the authors justified systematic approach to hygienic evaluation of aluminium plant reconstruction stages, for rational management in minimizing risk of environmental pollution and for health preservation.

[Follow-up monitoring of new inpatient cases of respiratory tuberculosis].

The optimum time of a follow-up of new cases of respiratory tuberculosis in the Republic of Sakha (Yakutia) is 3 years; by this time 91.8% of the patients may achieve a clinical recovery. Due to the climatic and geographic features of the region and to the logistic provision of tuberculosis dispensaries, the movement of patients by dispensary record groups by the regions is 0.

[Improved technology of chemotherapy of pulmonary tuberculosis complicated by other diseases].

Ample clinical material obtained in Yakutia was used to study the efficiency of combined treatment in patients with disseminated pulmonary tuberculosis concurrent with gastrointestinal and respiratory diseases. At the same time it was justifiable to employ alternatives to deliver antituberculous agents to the lesion focus (rectal dropwise administration, phono- and photophoresis of isoniazid, endobronchial colloid diluted rifampicin, and activated silver water diluted antituberculous drugs) with additional biophysical exposure. This made this group of patients have much better antituberculous agent intolerance, which increased nonbacterial isolation rates and closed decay cavities as compared with conventional methods for administering antituberculous agents.

[Use of external laser radiation in patients with infiltrative pulmonary tuberculosis].

A procedure has been developed for the use of semiconductor laser radiation in the combined drug therapy of patients with disseminated infiltrative pulmonary tuberculosis with multiple destructions and massive bacterial excretion, by increasing the number of sessions, which reduces the time of bacterial excretion cessation by 2-4 weeks, decay cavity closure by a months, and hospital treatment by 1.5 months and promotes minimal residual changes in most of them.

[Treatment of tuberculosis patients with massive bacterial excretion].

A new endobronchial treatment has been developed for patients with destructive pulmonary tuberculosis with massive bacterial excretion, complicated by chronic nonspecific endobronchitis. The treatment includes inhalation therapy with antituberculous drugs dissolved in activated silver water. This treatment of 42 patients has shown more than 2-fold increases in the rate of massive bacterial excretion cessation.