Inbreeding and high developmental temperatures affect cognition and boldness in guppies ().

Inbreeding impairs the cognitive abilities of humans, but its impact on cognition in other animals is poorly studied. For example, environmental stress (e.g.

Application of zirconium aspartic acid metal-organic framework (MIP-202(Zr)) for high efficient ruthenium adsorption from aqueous solutions.

The zirconium metal - organic framework MIP-202(Zr), based on L-aspartic acid, was prepared by hydrothermal method and used for study of ruthenium adsorption from aqueous solutions. The obtained material was characterized by X-ray diffraction (XRD), infra red spectroscopy (IR), thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), scanning electron microscopy (SEM) and X-ray photoelectron spectroscopy (XPS). The batch adsorption experiment was performed for determination of adsorption equilibrium, kinetics and thermodynamics parameters to Ru(III) from aqueous solution on MIP-202(Zr).

Crystalline germanium high-Q microresonators for mid-IR.

High-quality-factor optical microresonators have become an appealing object for numerous applications. However, the mid-infrared band experiences a lack of applicable materials for nonlinear photonics. Crystalline germanium demonstrates attractive material properties such as high nonlinear refractive index, large transparency window including the mid-IR band, particularly long wave multiphonon absorption limit.

[Clinical guidelines for male infertility: controversial issues and the need to reach interdisciplinary consensus].

A review of controversial issues about the terminology on male infertility and reproductive function, which is currently used, as well as proposals for updating clinical guidelines for the diagnosis and treatment of male infertility and men in infertile couples are presented in the article. An algorithm is described, the elements of which ensure referral of patients based on the possibility and timing of restoration of reproductive function, taking into account the reproductive health of a woman, as well as increasing the likelihood of successful treatment aimed at the birth of a healthy child.

A case of relapsed acute myeloid leukemia mimicking acute otomastoiditis.

Key Clinical Message: Identifying myeloid sarcoma in rare locations is a diagnostic challenge and requires careful evaluation. The optimal management of extramedullary disease requires further investigation, but tissue biopsy and a personalized approach are crucial.

Abstract: Herein, we describe an unusual case of acute myeloid leukemia presenting with an isolated involvement of the temporal bone after a complete remission of systemic disease for more than a year.

Epigenomic Profiling Advises Therapeutic Potential of Leukotriene Receptor Inhibitors for a Subset of Triple-Negative Breast Tumors.

Triple-negative breast cancer (TNBC) is the most aggressive molecular subtype, with a poor survival rate compared to others subtypes. For a long time, chemotherapy was the only systemic treatment for TNBC, and the identification of actionable molecular targets might ultimately improve the prognosis for TNBC patients. We performed a genome-wide analysis of DNA methylation at CpG islands on a collection of one hundred ten breast carcinoma samples and six normal breast tissue samples using reduced representation bisulfite sequencing with the XmaI restriction enzyme (XmaI-RRBS) and identified a subset of TNBC samples with significant hypomethylation at the genes' CpG islands, including CpG dinucleotides covered with cg12853742 and cg21886367 HumanMethylation 450K microarray probes.

[The role of doppler ultrasound in the scrotal and penile trauma].

Introduction: The injuries of the external genital organs in men accounts for 30-50% of the total number of injuries of genitourinary system. In half of the cases, there is a trauma of the penis. In 80% of cases, trauma of the penile or scrotal area occurs.

[Treatment of infertility in men with pathospermia associated with oxidative stress].

Introduction: Oxidative stress considered to be the main cause of male infertility. Surgical treatment of varicocele and elimination of the inflammatory process in the male accessory glands can help reduce the level of oxidative stress, however, in most cases, antioxidant therapy is additionally prescribed. Currently, much attention is paid to regulatory peptides as a component of antioxidant therapy due to their antioxidant, anti-inflammatory and immunomodulatory properties.

DNA Methylation and Prospects for Predicting the Therapeutic Effect of Neoadjuvant Chemotherapy for Triple-Negative and Luminal B Breast Cancer.

Despite advances in the diagnosis and treatment of breast cancer (BC), the main cause of deaths is resistance to existing therapies. An approach to improve the effectiveness of therapy in patients with aggressive BC subtypes is neoadjuvant chemotherapy (NACT). Yet, the response to NACT for aggressive subtypes is less than 65% according to large clinical trials.

Photobase-Triggered Formation of 3D Epitaxially Fused Quantum Dot Superlattices with High Uniformity and Low Bulk Defect Densities.

Highly ordered epitaxially fused colloidal quantum dot (QD) superlattices (epi-SLs) promise to combine the size-tunable photophysics of QDs with the efficient charge transport of bulk semiconductors. However, current epi-SL fabrication methods are crude and result in structurally and chemically inhomogeneous samples with high concentrations of extended defects that localize carriers and prevent the emergence of electronic mini-bands. Needed fabrication improvements are hampered by inadequate understanding of the ligand chemistry that causes epi-SL conversion from the unfused parent SL.

Free energy difference to create the M-OH intermediate of the oxygen evolution reaction by time-resolved optical spectroscopy.

Theoretical descriptors differentiate the catalytic activity of materials for the oxygen evolution reaction by the strength of oxygen binding in the reactive intermediate created upon electron transfer. Recently, time-resolved spectroscopy of a photo-electrochemically driven oxygen evolution reaction followed the vibrational and optical spectra of this intermediate, denoted M-OH. However, these inherently kinetic experiments have not been connected to the relevant thermodynamic quantities.

Coherent Acoustic Interferometry during the Photodriven Oxygen Evolution Reaction Associates Strain Fields with the Reactive Oxygen Intermediate (Ti-OH*).

The oxygen evolution reaction (OER) from water requires the formation of metastable, reactive oxygen intermediates to enable oxygen-oxygen bond formation. Conversely, such reactive intermediates could also structurally modify the catalyst. A descriptor for the overall catalytic activity, the first electron and proton transfer OER intermediate from water, (M-OH*), has been associated with significant distortions of the metal-oxygen bonds upon charge-trapping.

The electron-transfer intermediates of the oxygen evolution reaction (OER) as polarons by spectroscopy.

The conversion of diffusive forms of energy (electrical and light) into short, compact chemical bonds by catalytic reactions regularly involves moving a carrier from an environment that favors delocalization to one that favors localization. While delocalization lowers the energy of the carrier through its kinetic energy, localization creates a polarization around the carrier that traps it in a potential energy minimum. The trapped carrier and its local distortion-termed a polaron in solids-can play a role as a highly reactive intermediate within energy-storing catalytic reactions but is rarely discussed as such.

Ultrafast vibrational dynamics of the tyrosine ring mode and its application to enkephalin insertion into phospholipid membranes as probed by two-dimensional infrared spectroscopy.

Enkephalins are small opioid peptides whose binding conformations are catalyzed by phospholipid membranes. Binding to opioid receptors is determined by the orientation of tyrosine and phenylalanine side chains. In this work, we investigate the effects of different charged phospholipid headgroups on the insertion of the tyrosine side chain into a lipid bilayer using a combination of 2D IR spectroscopy, anharmonic DFT calculations, and third order response function modeling.

[Soft tissue clear cell sarcoma. A report of three cases].

The paper describes three cases of soft tissue clear cell sarcoma, a rare melanin-producing malignant tumor, which is diagnosed in 52-to-87-year-old women. It provides a clinical and morphological description of the tumor and the results of immunohistochemical tests.

[Association of tension-free inguinal hernia repair and pathospermia in fertile men].

Objective: To reveal the association of tension-free inguinal hernia repair and pathospermia in fertile men.

Material And Methods: We have retrospectively analyzed medical records of 512 men who appealed to andrologist with complaints of the absence of pregnancy in wife in 2018. We evaluated duration and features of infertility, presence/absence of previous inguinal hernia repair, spermogram data (according to WHO criteria, 2010) in all patients.

DNA methylation markers panel can improve prediction of response to neoadjuvant chemotherapy in luminal B breast cancer.

Despite the advantages of neoadjuvant chemotherapy (NACT), associated toxicity is a serious complication that renders monitoring of the patients' response to NACT highly important. Thus, prediction of tumor response to treatment is imperative to avoid exposure of potential non-responders to deleterious complications. We have performed genome-wide analysis of DNA methylation by XmaI-RRBS and selected CpG dinucleotides differential methylation of which discriminates luminal B breast cancer samples with different sensitivity to NACT.

[Immunohistochemical study of the MSI phenotype of urothelial bladder cancer].

Objective: To investigate the MSI phenotype of urothelial bladder cancer (BC) by immunohistochemistry (IHC) and to assess its relationship to the prognostic factors of the disease and PD-L1 status of BC.

Material And Methods: Using the surgical and biopsy materials obtained from 50 patients with BC during examination and treatment, the investigators studied the MSI phenotype by IHC. A system was proposed to assess the IHC expression of MSI proteins, by taking into account the intensity of nuclear staining and the area occupied by tumor cells with stained nuclei.

Risk factors and urinary biomarkers of non-albuminuric and albuminuric chronic kidney disease in patients with type 2 diabetes.

Background: A number of recent studies indicate a transformation in the natural course of chronic kidney disease (CKD) in type 2 diabetes (T2D) patients: an increasing prevalence of declined renal function without proceeding to the accompanying elevation of albuminuria. It has been suggested that albuminuric and non-albuminuric CKD patterns could be different in their phenotypes and pathogenic mechanisms.

Aim: To identify the risk factors and biomarkers of albuminuric and non-albuminuric patterns of CKD in patients with T2D.

Optimized noise reduction scheme for heterodyne spectroscopy using array detectors.

In this work, we optimize and further advance a noise reduction scheme for heterodyne spectroscopy. This scheme linearly combines data from reference detectors to predict the noise statistics in the signal detector through an optimized coefficient matrix. We validate this scheme for visible white-light-continuum and 800-nm light sources using un-matched CMOS arrays and show that the signal-to-noise ratio can approach the noise floor of the signal detector while using only ~5% of the energy for reference detection.

[Long-term results of the first treatment of men with May-Thurner syndrome and varicose veins of pelvic organs].

Recurrent and bilateral varicocele represent two least studied aspects of the disease. There is no recommendation in current urological and andrological guidelines in various countries on the diagnosis and treatment of such patients. The first experience of successful surgical treatment of a patient with recurrent varicocele due to May-Thurner syndrome is presented in this paper.

[Docosahexaenoic acid in the treatment of idiopathic male infertility].

Aim: docosahexaenoic acid is one of the most common fatty acids in the cell membranes of sperm. This substance is a structural component of cell membranes, and is responsible for such properties as plasticity and fluidity which are necessary for the implementation of the process of capacitation and acrosome reaction. In addition, docosahexaenoic acid has antioxidant properties.

[PD-L1 status in breast cancer].

Objective: To investigate the expression of PD-L1 in triple-negative and luminal B, HER2-negative breast carcinoma and to assess the association of the tumor PD-L1 status with the prognosis of the disease.

Subject And Methods: The PD-L1-status of primary tumor was studied in 72 patients with breast cancer, by using an immunohistochemical method.

Results: Differences were found in the incidence of carcinomas with PD-L1 expression in tumor cells depending on the molecular genetic type: there was a positive PD-L1 status in luminal B, HER2-negative tumors in 4 (14.