Publications by authors named "Vinodhini K"
Introduction: The hallmark of chronic myeloid leukemia (CML) is the presence of Philadelphia chromosome, its resultant fusion transcript (BCR-ABL1), and fusion protein (p210). Alternate breakpoints in BCR (m-bcr, μ-bcr, and others) or ABL1 result in the expression of few rare fusion transcripts (e19a2, e1a2, e13a3, e14a3) and fusion proteins (p190, p200, p225) whose exact clinical significance remains to be determined.
Methods: Our study was designed to determine the type and frequency of BCR-ABL1 fusion transcripts in 1260 CML patients and to analyze the prognosis and treatment response in patients harboring rare BCR-ABL1 fusion transcripts.
The quest for exploring new frontiers in the field of medical science for efficient and improved treatment modalities has always been on a rise. Extracorporeal shock wave therapy (ESWT) has been enormously used in medical practice, principally, for the management of urolithiasis, cholelithiasis and also in various orthopedic and musculoskeletal disorders. The efficacy of ESWT in the stimulation of osteoblasts, fibroblasts, induction of neovascularization and increased expression of bone morphogenic proteins has been well documented in the literature.
View Article and Find Full Text PDFPurpose: Alteration and overexpression of HER2 proto-oncogene have been implicated in the carcinogenesis and prognosis of ovarian cancer. We evaluated this hypothesis among women with ovarian carcinoma patients from Tiruchirapalli, Tamil Nadu, India.
Methods: Genomic DNA was extracted from 72 case patients and 288 control subjects and was examined for I655V polymorphism by PCR-RFLP based assay.
Objective: To assess the prevalence of HPV infection among women with cervical cancer in Tiruchirapalli, Tamil Nadu, India.
Methods: A case-control study was conducted with 246 women with cervical cancer and 257 control participants aged between 20 and 70 years. The presence of HPV DNA was determined using the MY09/11 PCR protocol, the GP5(+)/6(+) PCR protocol, and type-specific PCR-based assays.
Purpose: The study aimed to identify the status of HPV infection among young sexually unexposed girls from Tiruchriapalli district, Tamilnadu, India.
Methods: The distribution of HPV genotypes was evaluated by PCR DNA genotyping after self sampling from 246 study subjects.
Results: Positivity for HPV DNA was reported among 9.
Viral and bacterial aetiologies of epithelial ovarian cancer.
Eur J Clin Microbiol Infect Dis
September 2012
We sought to analyse the presence of human papillomavirus (HPV), Chlamydia trachomatis and cytomegalovirus (CMV) infection in women with epithelial ovarian carcinomas. Polymerase chain reaction (PCR)-based detection of microbial infections was carried out. A total of 39 tissue samples were analysed with consensus and type-specific primers for HPV, primers specific for the cryptic plasmid of Chlamydia and primers for glycoprotein B of CMV.
View Article and Find Full Text PDFObjective: We set to estimate the genotype-specific prevalence of human papilloma virus (HPV) and its associated risk factors responsible among women with normal and abnormal cytology by systematic literature survey.
Methods: Reports on HPV prevalence published between 2000 and 2011 were retrieved. To be included, studies required information on cervical cytology, plus detailed descriptions of study populations, methods used to collect cervical samples, and assays used for HPV DNA detection and typing.
Background: Composing of less than 1% of all ovarian cancers, immature teratoma is a malignancy that mainly affects the young, and they present with advanced disease. The treatment of immature teratoma is conservative primary surgery usually involving unilateral salpingo-oophorectomy followed by combination chemotherapy.
Case Presentation: Here we present a case of a 68 year old woman with bilateral ovarian teratoma complicated with carcinosarcoma.