pH-modulated self-assembly of colloidal nanoparticles in a dual-droplet inkjet printing process.

Hypothesis: Interfacial self-assembly has been demonstrated as a powerful driving mechanism for creating various nanostructured assemblies. In this work, we employed a dual-droplet printing process and interfacial self-assembly mechanism to produce deposits with controlled assembly structures of colloidal nanoparticles. We hypothesize that pH modulation of the droplet will influence the interfacial self-assembly through the multibody interactions, e.

Amorphous-state characterization of efavirenz--polymer hot-melt extrusion systems for dissolution enhancement.

The aim of this study was to improve the dissolution rate of efavirenz (EFV) by formulating a physically stable dispersion in polymers. Hot-melt extrusion (HME) was used to prepare solid solutions of EFV with Eudragit EPO (a low-glass transition polymer) or Plasdone S-630 (a high-glass transition polymer). The drug-polymer blends were characterized for their thermal and rheological properties as a function of drug concentration to understand their miscibility and processability by HME.

Methylene green electrodeposited on SWNTs-based "bucky" papers for NADH and l-malate oxidation.

This research introduces a cavity anode design based on new single-walled nanotube (SWNTs) papers, "bucky" papers, used for the oxidation (and regeneration) of nicotinamide adenine dinucleotide (NADH) and the oxidation of l-malate. The materials designed are paper-like processed composites containing also additives: BP11 sample contains SWNTs and isopropanol (IPA); the BPMG sample contains SWNTs, IPA, and methylene green (MG). NADH/NAD(+) is the cofactor responsible for the oxidation of l-malate by malate dehydrogenase (MDH), in the Krebs' cycle.

Lyotropic liquid crystalline self-assembly in dispersions of silver nanowires and nanoparticles.

We report demixed nematic lyotropic liquid crystalline phase formation in dispersions of silver nanowires and spherical nanoparticle aggregates in ethylene glycol and water. This phase is observed in samples in spite of the high density, large aspect ratio, and long relaxation times of the nanowires which have an average length of 6.8 microm.

Eudragit NE30D based metformin/gliclazide extended release tablets: formulation, characterisation and in vitro release studies.

Metformin/Gliclazide extended release tablets were formulated with Eudragit NE30D by wet granulation technique. Two batches were prepared in order to study influence of drug polymer ratio on the tablet formation and in vitro drug release. The formulated tablets were characterized by disintegration time, hardness, friability, thickness, weight variation, and in vitro drug release.