Publications by authors named "Vinod Kumar Bhaskara Pillai"
Different patterns of expansion, contraction and memory differentiation of HIV-1 Gag-specific CD8 T cells elicited by adenovirus type 5 and modified vaccinia Ankara vaccines.
Vinod Kumar Bhaskara Pillai Sunil Kannanganat Pablo Penaloza-Macmaster Lakshmi Chennareddi Harriet L Robinson
Vaccine
July 2011
The magnitude and functional quality of antiviral CD8 T cell responses are critical for the efficacy of T cell based vaccines. Here, we investigate the influence of two popular viral vectors, adenovirus type 5 (Ad5) and modified vaccinia Ankara (MVA), on expansion, contraction and memory differentiation of HIV-1 Gag insert-specific CD8 T cell responses following immunization and show different patterns for the two recombinant viral vectors. The Ad5 vector primed 6-fold higher levels of insert-specific CD8 effector T cells than the MVA vector.
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- - CD40L and GITRL are immune molecules from the tumor necrosis factor superfamily that can enhance vaccine effectiveness.
- - Previous research showed that a specific DNA vaccine in mice using multimeric forms of CD40L (multiple trimers) activated stronger CD8(+) T-cell responses compared to single or natural forms.
- - Similar multimeric versions were created for macaques, showing efficacy in stimulating B-cell and CD4(+) T-cell responses, offering promising tools for vaccine development against simian immunodeficiency virus.