Safety and tolerability of rivastigmine capsule with memantine in patients with probable Alzheimer's disease: a 26-week, open-label, prospective trial (Study ENA713B US32).

Objective: Rivastigmine, a dual cholinesterase inhibitor (ChEI), is widely approved for the symptomatic treatment of both mild-to-moderate Alzheimer's disease (AD) and Parkinson's disease dementia. Orally administered ChEIs may be associated with gastrointestinal (GI) side effects and add-on therapy with memantine, an N-methyl-d-aspartate receptor antagonist, approved for moderate-to-severe AD, may ameliorate such side effects. This was a 26-week, prospective, multicenter, single-arm, open-label pilot study to assess the safety and tolerability of rivastigmine capsules plus memantine in patients with moderate AD.

Biography of Sŏdhala and his contribution to Ayurvĕda.

Sŏdhala was a scholar of Ayurvĕda as well as săhitya, Jyotisya, Vyakaraņa and also a good poet who belongs to Gujarat. Sŏdhala contributed two important works to Ayurvĕda literature namely 1. Sŏdhbala nighaņţu, 2.

A review of Brahmavaivartapurana (BVP) with reference to Ayurveda.

Brahmavaivartapurana is one of the important Mahapurana, which is considered as a Vaisnavapurana. The text is divided into four parts called khanda i.e.

Biography of Bhăvamiśra author of Bhăvaprakăśa (a treatise of Laghutrayee).

Bhăvamiśra, the author of Bhăvaprakăśa was a great scholar in Samsŗt and ancient medical science. He set a great example to modernize ayurvĕda by incorporating new drugs, diseases, procedures of treatment etc. and making ayurvĕda up to date.

Medico-historical study of "Kilasa" (vitiligo/leucoderma) a common skin disorder.

The earliest known reference to Kilăsa was in 2200 B.C. in the period of Aushooryan.

Medicinal plants referred in Kautilya's Arthaśastra.

Kautilya's Arthaśastra which was written somewhere in 321-300 B.C. on ancient Indian Polity, holds a unique place in Indian history and culture.

Ayurvedic literature in Urdu part-III.

The present article is the continuation of the second part of the previous work published with the same title in the Bulletin of Indian Institute of History of medicine, Vol. XXIX. No.