Publications by authors named "Vinod B Patil"
Article Synopsis
- The PI3K pathway is essential for B-cell survival and is linked to B-cell cancers like DLBCL, with the overactivation of PI3Kδ being a significant factor.
- Small molecule inhibitors targeting PI3Kδγ, like LL-00084282, show promise in fighting DLBCL by demonstrating high potency and selectivity against this isoform while outperforming selective PI3Kδ inhibitors in cancer cell lines.
- LL-00084282 has shown effective results in vivo and exhibits good pharmacokinetic properties, indicating potential for future clinical trials in DLBCL patients and possible benefits in treating immunoinflammatory conditions.
α7 nicotinic acetylcholine receptor (α7 nAChR) is an extensively validated target for several neurological and psychiatric conditions namely, dementia and schizophrenia, owing to its vital roles in cognition and sensorimotor gating. Positive allosteric modulation (PAM) of α7 nAChR represents an innovative approach to amplify endogenous cholinergic signaling in a temporally restricted manner in learning and memory centers of brain. α7 nAChR PAMs are anticipated to side-step burgeoning issues observed with several clinical-stage orthosteric α7 nAChR agonists, related to selectivity, tolerance/tachyphylaxis, thus providing a novel dimension in therapeutic strategy and pharmacology of α7 nAChR ion-channel.
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