Transmigration of an Impacted Mandibular Canine: A Report of Two Cases.

Transmigration of an impacted mandibular canine is a rare entity. Published cases are scarce. The etiology and pathogenesis remain unclear.

Association between maternal vitamin D status during late pregnancy and acute lower respiratory tract infections and acute diarrheal disease during infancy - A cohort study.

Background: Acute lower respiratory tract infection (ALRI) and acute diarrheal disease (ADD) are the leading causes of mortality in children globally. There is emerging evidence of an association between maternal hypovitaminosis D and ALRI/ADD during infancy.

Objective: To determine whether maternal hypovitaminosis D (25(OH)D [<20 ng/ml] during late pregnancy is associated with increased risk of ALRI/ADD in their offspring during infancy.

Silver-catalyzed regioselective synthesis of pyrano heterocycles: a versatile route to samoquasine A derivatives.

This study introduces a silver-catalyzed method for the efficient and regioselective synthesis of pyrano heterocycles, utilizing readily available alcohols and water as nucleophiles. The method demonstrates high efficiency, delivering excellent yields and selectivity, and is scalable to gram quantities while maintaining broad functional group tolerance. Notably, the synthesized pyrano[3,4-]quinolines were successfully transformed into diverse samoquasine A derivatives, underscoring the method's applicability in natural product synthesis.

The pharmacological management of alcohol-related cirrhosis: what's new?

Introduction: Alcohol use disorder (AUD) is present in the majority of patients with alcohol-associated liver disease (ALD), which leads to about 50% of cirrhosis-related hospitalizations and over 25% of deaths worldwide. Patients with ALD often present at an advanced stage, like cirrhosis with its complications and alcohol-associated hepatitis (AH), which has high short-term mortality. Current treatments are limited, with the limited benefit of glucocorticoids only in the short-term among patients with AH, highlighting an urgent need for novel therapies.

Spatio-temporal breather dynamics in microcomb soliton crystals.

Solitons, the distinct balance between nonlinearity and dispersion, provide a route toward ultrafast electromagnetic pulse shaping, high-harmonic generation, real-time image processing, and RF photonic communications. Here we uniquely explore and observe the spatio-temporal breather dynamics of optical soliton crystals in frequency microcombs, examining spatial breathers, chaos transitions, and dynamical deterministic switching - in nonlinear measurements and theory. To understand the breather solitons, we describe their dynamical routes and two example transitional maps of the ensemble spatial breathers, with and without chaos initiation.

Measuring surface energy of solid surfaces using centrifugal adhesion balance.

The standard way to evaluate the solid surface energy using probe liquids relies on contact angle measurements. The measured contact angles rely on visible means and are different from their nanoscopic thermodynamic values. This compromises the surface-energy predictions so much that the surface energy-values can be hundreds of percentages higher than expected based on comparisons with different methods as reported in several studies.

A novel multi-model estimation of phosphorus in coal and its ash using FTIR spectroscopy.

The level of phosphorus must be carefully monitored for proper and effective utilization of coal and coal ash. The phosphorus content needs to be assessed to optimize combustion efficiency and maintenance costs of power plants, ensure quality, and minimize the environmental impact of coal and coal ash. The detection of low levels of phosphorus in coal and coal ash is a significant challenge due to its complex chemical composition and low concentration levels.

Characterization of novel natural cellulose fiber from for lightweight structural composite application and its effect on chemical treatment.

This study investigates tree bark fibers (FMB) as a sustainable alternative reinforcement for polymer composites. The Industrial Revolution marked the evolution of polymer composites with synthetic material reinforcement, leading to environmental concerns. Natural fibers have recently gained prominence as efficient alternatives for polymer composites.

A Short Review on the Evolution of Magnetocaloric La(Fe,Si) and Its Fabrication through Melt Spinning.

Energy-efficient refrigeration technology needs to advance ineluctably due to rising energy consumption and diminishing fossil fuel and primitive hydrocarbon reserves. Further, the existing gas compression method releases huge amount of chlorofluorocarbons (CFCs) that deplete the ozone layer. This is a global concern, which demands an immediate remedial technology.

Sustainable Synthesis of Indole-Substituted Densely Functionalized Pyrrole.

A novel chromatography- and catalyst-free methodology has been developed for the synthesis of poly substituted pyrrole in good yields via a multicomponent reaction of arylglyoxal, 1,3-dicarbonyl, indole, and aromatic amine. This strategy provides various advantages such as simple experimental and workup procedures, mild reaction conditions, no added catalyst, use of green solvent, and simple purification procedure of pure product without using column chromatography. This green method offers a simple and highly effective strategy to synthesize a wide range of indole-pyrrole conjugates in a one-pot operation.

Orthostatic hypotension in the elderly: Prevalence and its management by simple isometric limb tensing exercises.

Objective: Orthostatic hypotension (OH), an important cause of falls in the elderly, is grossly underdiagnosed. Our study aimed to determine the prevalence and associated factors of OH among the elderly attending a secondary care hospital. Furthermore, we assessed and compared the effectiveness of simple arm and leg tensing exercises, performed just prior to standing, to mitigate the orthostatic fall in blood pressure (BP) in elderly OH patients.

Correlation of Beta Trace Protein Levels with Serum Creatinine-Based Estimated Glomerular Filtration Rate Equations in Chronic Kidney Disease.

Estimated GFR (eGFR) is calculated using serum creatinine (SCr) based equations which have their own limitations. Novel biomarkers like beta trace protein (BTP) are studied for eGFR estimation. The aim of this study is to determine the serum levels of BTP in healthy controls and chronic kidney disease (CKD) cases and to find out the correlation of BTP levels with that of SCr and SCr-based eGFR formulas.

Signal Selection Technique based on Statistical Approach for Enhanced Detection of Single-trial Auditory Evoked Potentials.

Volume conduction from insignificant neuronal sources in the brain poses a challenge to the detection and classification of single-trial low amplitude evoked potentials in electroencephalograph (EEG). This work presents a statistical signal selection method for enhanced detection of single-trial EEG auditory evoked potential (AEP) elicited in the brain in response to subjects' own name audio stimulus. The proposed method comprises of a signal selection stage based on a statistical analysis followed by a support vector machine (SVM)-based classifier.

A Phase-based EEG Epoch Selection Method for Decoding Bi-directional Hand Movement Imagination in Stroke Patients.

Electroencephalogram (EEG) based non-invasive Brain Computer Interface (BCI) system is gaining significant attention as a promising solution for stroke rehabilitation. Accurate selection of informative EEG time segment, that accommodates the specific neural activity patterns associated with the underlying mental task can help to improve the efficacy of the BCI system. In this work, we propose a phase-based EEG epoch selection algorithm to extract the discriminative EEG time segment corresponding to bi-directional hand motor imagery.

Gels That Serve as Mucus Simulants: A Review.

Mucus is a critical part of the human body's immune system that traps and carries away various particulates such as anthropogenic pollutants, pollen, viruses, etc. Various synthetic hydrogels have been developed to mimic mucus, using different polymers as their backbones. Common to these simulants is a three-dimensional gel network that is physically crosslinked and is capable of loosely entrapping water within.

Perceptions and practices related to menstruation and reproductive health in adolescent girls in an urban population - A cross sectional study.

Introduction: Menarche is an important biological milestone in a woman's life as it marks the onset of the reproductive phase of her life. It is, often considered an impure phenomenon in Indian society owing to cultural taboos and insufficient and incorrect information and causes unnecessary restrictions in the day-to-day normal activities of menstruating girls.

Aim: To assess the perception and practices related to menstruation and reproductive health among school-going adolescent girls in the urban population in Kochi, Kerala.

Study on acute respiratory infection in children aged 1 year to 5 years-A hospital-based cross-sectional study.

Background: Acute respiratory infections (ARIs) are the single greatest cause of death among children throughout the world. They are responsible every year for the deaths of 4.3 million children under 5 years of age worldwide.

Primary neuroendocrine breast cancer-an unusual occurrence.

Primary breast neuroendocrine neoplasms (BNENs) are a rare form of breast cancer, accounting for less than 0.1% of all breast malignancies. These neoplasms have a similar clinical presentation as conventional breast carcinomas, differing mainly in their histopathology and expression of neuroendocrine (NE) markers, chromogranin and synaptophysin.

Recent advancements in lignocellulose biomass-based carbon fiber: Synthesis, properties, and applications.

A growing need to reduce the global carbon footprint has prompted all sectors to make significant efforts in this direction. For example, there has been much focus on green carbon fiber sustainability. For example, it was found that the polyaromatic heteropolymer lignin might act as an intermediary in synthesising carbon fiber.

Deuterated driven new chemical entities: An optimistic way to improve therapeutic efficacy.

In organic chemistry, the use of deuterium exchange as a tool to study the mechanism of chemical reaction has been well explored. Since two decades, the research focus on deuterated bioactive molecules has been gaining attention for investigating the therapeutic potential of deuterium replacement in a chemical structure. Recently, Food Drug Administration (FDA) approved the first deuterium-labeled drug "deutetrabenazine", and notified the deuterated drugs as new chemical entities (NCEs).

Dental Considerations for the Treatment of Patients with Morquio Syndrome.

Aim: Morquio syndrome, also called Mucopolysaccharidosis IV (MPS IV), is a rare autosomal recessive metabolic lysosomal disorder that results in the deposition of glycosaminoglycans (GAGs) in various tissues and organs, resulting in an array of signs and symptoms. The aim of the study was to systematically record the clinical features with a special emphasis on oral manifestations of patients diagnosed with MPS IV and asses the dental treatment implications of the disease manifestations.

Materials And Methods: A cross-sectional study was conducted on patients diagnosed with MPS IV ( = 26).

Primary Reconstruction in Segmental Resection of Mandible-An Outcome Analysis of Different Reconstructive Techniques.

Functional and cosmetic defects in the maxillofacial region may result from trauma, inflammatory disease, benign or malignant tumors. There are several well established reconstructive options for restoring mandibular continuity and function. Traditionally, surgeons have used their past experience to determine the best way to perform the osteotomy, graft harvesting, and graft shaping procedures for mandibular reconstruction.

DPIO Function among Normal Hearing Middle-Aged Adults in Sudarshan Kriya Yoga Practitioners and Non-Practitioners.

The cochlea, to function efficiently towards hearing, the oxygenated blood supply is a very essential component. Yoga, a practice that originated in ancient India, claims to facilitate physical, mental, and spiritual well-being. Sudarshan Kriya Yoga (SKY) is one such practice that focuses on breathing, therefore, regulating the oxygen circulation in our body.

Validated HPLC-UV method for quantification of paxalisib, a pan PI3K and mTOR inhibitor in mouse plasma: Application to a pharmacokinetic study in mice.

Paxalisib is a pan-PI3K and mTOR inhibitor, currently entering into Phase II clinical trials as a potential drug to treat glioblastoma patients. We report the development and validation of a high-performance liquid chromatography (HPLC) method for the quantitation of paxalisib in mouse plasma as per the US Food and Drug Administration regulatory guidelines. From the mouse plasma, paxalisib and the internal standard (IS; filgotinib) were extracted using ethyl acetate as an extraction solvent.