[Clinical immunological diagnostics of overlap syndrome during autoimmune hepatic disorders].

The complex determination of serum autoantibodies to hepatic antigens using enzyme immunoassay and immunoblot allows to increase the frequency of overlap syndrome identification during autoimmune hepatic disorders and its early diagnostics, that has a big clinical, diagnostic and prognostic importance. The levels of overlap autoantibodies combine with biochemical index and with disease activity and intensity of autoimmune processes during overlap syndrome of primary biliary cirrhosis/autoimmune hepatitis (PBC/AIH).

[Syndrome of overlap of autoimmune hepatitis and primary biliary cirrhosis with the outcome in cirrhosis of the liver, complicated by fatal bleeding in the small intestine].

The authors presents the clinical case of autoimmune overlap syndrome: autoimmune hepatitis and primary biliary cirrhosis with outcomes in the hepatic cirrhosis complicated fatal intestinal bleeding.

[Diagnostic value of serum markers of fibrosis in chronic liver diseases].

Aim: To estimate the diagnostic value (DV) of direct markers of liver fibrosis, such as type IV collagen (C-IV), hyaluronic acid (HA), tissue inhibitor of metalloproteinases-1 (TIMP-1) in combination with indirect markers of fibrosis, such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), and gamma-glutamyl transpeptidase (gamma-GTP), alkaline phosphatase (ALP), platelets, tumor necrosis factor-alpha (TNF-alpha) in evaluating liver fibrosis.

Subjects And Methods: Sixty-seven patients with chronic diffuse liver diseases were examined. ALT, AST, gamma-GTP, and ALP were determined as indirect indicators of fibrosis.

[Primary non-Hodgkin lymphoma of the liver in patients with chronic virus].

The article provides a brief overview of recent data on non-Hodgkin's lymphoma. We describe a special case primary isolation non-Hodgkin's lymphoma of the liver in a patient with chronic hepatitis C. Were analyzed medical errors at all stages of inspection and treatment of the patient.

[Spontaneous bacterial peritonitis in liver cirrhosis: optimization issues of prevention and treatment].

Research of features of a current of a spontaneous bacterial peritonitis (SBP) allows to allocate close interrelation between SBP, system inflammatory reaction and a sepsis to consider SBP, as one of stages in evolution of the difficult infectious process caused, as a rule, by resident flora, developing at patients with decompensated liver cirrhosis (LC), which demands timely preventive maintenance and adequate antibacterial therapy. In the present work therapy and preventive maintenance SBP questions are considered. In article the extensive review of the data of the literature and own supervision by efficiency of treatment SBP also is presented.

[Diagnostic value of autoantibodies to asialoglycoprotein receptor in autoimmune hepatitis].

Among 106 patients with autoimmune liver disease in 12 (11.3%) were found autoantibodies to asialoglycoprotein receptor (anti-ASGPR): in 5 (9.1%) of 55 with PBC, and 4 (17.

[Features of the HCV-infection in the elderly patients].

The problem of chronic HCV-infection in the elderly patients is poorly known. During the HCV-infection and progression of fibrosis in chronic liver diseases depends on age of the patient.

[Spontaneous bacterial peritonitis: scientific and practical achievements and prospects].

We presented the results of our research in comparison with the literature on the etiology, pathogenesis and diagnosis of spontaneous bacterial peritonitis (SBP) at liver cirrhosis (LC), complicated by ascites. Based on these data, was proposed a classification of SBP. Were identified criteria for early diagnosis of SBP on the basis of clinical manifestations of bacterial peritonitis, systemic inflammatory response, results of studies of ascitic fluid (AF) using gas chromatography-mass spectrometry (GC-MS).

[Spontaneous bacterial peritonitis and systemic inflammatory reaction in hepatic cirrhosis patients].

Aim: To develop criteria of early diagnosis of spontaneous bacterial peritonitis (SBP) in hepatic cirrhosis (HC).

Material And Methods: Clinical symptoms of SBP including systemic inflammatory reaction were analysed in 286 patients. The count of polymorphonuclear neutrophils (PNL) in ascitic liquid (AL), microbiological study of the blood and AL were made.

[Effectiveness of the new plant hepatoprotector--Ropren in patients with non-alcoholic steatohepatitis].

Liver damage causes serious metabolic disorders, immune response, detoxification functions and antimicrobial protection. Therefore, the problem of finding new high effective drugs for the restoration and normalization of liver function is extremely urgent. This article presents a new domestic plant hepatoprotector Ropren, which is a biopolymer polyprenols isolated from the green of pine and spruce, and an analog of the endogenous lipid--dolichol.

[The diagnostic significance of ultrasound elastometry in evaluation of fibrosis in chronic diffuse liver diseases].

The Purpose Of The Study: Determination of the diagnostic value of ultrasound elastometry of liver (UEL) in the assessment of liver fibrosis in patients with chronic diffuse liver diseases (CDLD).

Material And Methods: The study involved 316 patients with various etiologies of the CDLD, with the underwent both liver biopsy, the UEL, and evaluation of fibrosis (F) according to the Metavir classification.

Results: The maximum diagnostic accuracy of the UEL was obtained in determining of the 4-th stage of fibrosis according to the Metavir.

[Autoimmune reactions in diseases of the digestive system organs].

Aim: To examine content, diagnostic and prognostic role of autologous antibodies in gastrointestinal diseases (GID).

Material And Methods: Enzyme immunoassay was used to measure content of autologous antibodies to N+/K+ ATPase (Aab) of gastric parietal cells, mitochondria, microsomes, tissue transglutaminase in blood serum of 196 patients with gastric, gallbladder, small and large intestinal diseases. Aab relations with heterologous antibodies were studied with kits provided by Bektor-Best (Novosibirsk), DRG-Diagnostics, Orgentec (Germany) and others.

[Diagnosis of spontaneous bacterial peritonitis in liver cirrhosis].

Working out of the new methodical approaches of diagnostics and treatment of spontaneous bacteriological peritonitis (SBP) in the patients with cirrhosis of the liver (CL). The ascitic liquid (AL) was examined in 35 patients with CL by the method of gas chromatography--mass-spectrometry (GCH-MS). The results of quantitative and qualitative examination of the chemical components--markers of potential infection (aerobe and anaerobe) with the GCH-MS method testify to the infected AL.

[Liver cirrhosis of alcoholic etiology complicated by the spontaneous bacterial peritonitis].

The case of spontaneous bacterial peritonitis (SBP) in the patient, with alcoholic cirrhosis, is presented in the article. Clinical observation demonstrates diagnostic hardships of latent clinical course of alcoholic cirrhosis, complicated SBP. Clinical observation demonstrated diagnostic consequence of ultrasound elastometry.

[Lactulose in treatment of hepatic encephalopathy in patient with liver cirrhosis].

Our research demonstrated the high efficiency of using lactulose in patients with the latent and first grades of portal-systemic encephalopathy. Lactulose is an efficient and safe remedy, and its consistent application prevents the development of portal-systemic encephalopathy and makes it possible to control the level of hyperammonemia and improve a patient's quality of life.

[Metabolism pathways and use of heptral in chronic liver diseases].

Heptral (Ademetionine) plays one of the main functions in the intermediate metabolism, takes part in the processes of methylation and transulfurization and aminopropylation. The use of Heptral in patients with chronic liver diseases with accompanying holystase and encephalopathy of different degree, at depressions, related to alcohol and toxic liver disorders, is pathogenically reasoned for prevention of liver encephalopathy.

[Cells of the "hand mirror" type in lymphoblastic leukemia in children].

Based on cytochemical studies of the surface antigens and receptors, a lymphoid nature of "hand mirror" type cells was established in 24 children with an acute lymphoblastic leukemia. Their identity to the cells typical of the disease variant termed formerly an acute lymphoreticulosis is shown.