[Identification of changes in gene loci potentially associated with cervical cancer using NotI microarrays].

The investigation of the cancer-associated structural and epigenetic changes in cell genome is a major approach for understanding mechanisms of cancerogenesis. To investigate these genome changes, novel technique of microarrays comprising NotI-linking genome clones was developed. Twenty eight samples from patients with cervical cancer were analyzed using NotI microarrays of human chromosome 3.

[GABA metabolism and contents of neuroactive amino acids in rat brain after acute morphine administration].

The activities of GABA-catabolizing enzymes (GABA-transaminase and succinic semialdehyde dehydrogenase), succinate dehydrogenase, alanine and aspartate amino transferases, the contents of GABA, glutamate, glutamine, alanine, aspartate and glycine were studied in rat brain regions after acute morphine administration. Intraperitoneal (i.p.

[The use of neoadjuvant intra-arterial polychemotherapy in the treatment of cancer of the genitalia].

Results are submitted of employment of intraarterial superselective polychemotherapy in the treatment of malignant tumors of female genital organs in 106 patients; of these, forty individuals presented with carcinoma of the neck of the womb, 33 with tumours of the trophoblast, 18 had carcinoma of the ovaries, and 15 carcinoma of the body of the womb. A clinical analysis was done of the results obtained as were clinical-morphological correspondences (there has been studied a therapeutic pathomorphosis of the tumours) depending on the disease stage, individual schemes of polychemotherapy. The greatest benefit from the above treatment occurred in proliferative and invasive vascular mole and choriocarcinoma; patients with carcinoma of the neck and body of the womb derived less benefit, those with carcinoma of the ovaries experienced the least therapeutic effect.

[Possibilities of preclinical and differential diagnosis of malignant neoformations according to the percentage of large granular lymphocytes].

The paper discusses the results of application of a simple and easily available method of measuring levels of large granule-containing lymphocytes for identification of risk for cancer during mass screenings and differential diagnosis of benign and malignant tumor before morphological examination.