Publications by authors named "Vinicius Santos Nunes"
Background: Hepatoportal sclerosis HPS or obliterative portal venopathy (OPV), one of the differential diagnoses for non-cirrohtic portal hypertension, is characterized by the disappearance of the portal branches, portal and septal fibrosis, perisinusoidal fibrosis and regenerative nodular hyperplasia (RNH). It is a spectral disease that may progress to severe portal hypertension. Its etiopathogenesis is still little understood, especially in Brazil, it has been probably misdiagnosed due to its histopatological similarities with the hepatosplenic form of schistosomiasis.
View Article and Find Full Text PDFBackground: Drug-induced liver injury is still misunderstood in Brazil due to diagnostic difficulties or lack of reporting incidents.
Objective: To assess the frequency of adverse events related to the use of medicines in a primary healthcare unit, in a city locate southwestern of the state of Bahia, Brazil.
Methods: Prospective study conducted at the Primary Center for Specialized Health (CEMEA), February at August of 2013 in Vitoria da Conquista, Bahia, Brazil.
Article Synopsis
- The standard treatment for certain autoimmune diseases uses corticosteroids and thiopurines, with metabolite measurement helping non-responders identify effective strategies.
- Many patients convert thiopurines into a potentially harmful metabolite (6-MMP) instead of the desired immune-suppressing one (6-thioguanine), but adding allopurinol helps shift this balance.
- A case study shows a 51-year-old woman with autoimmune hepatitis achieved histological remission after adding allopurinol to her treatment, reducing her azathioprine dosage significantly without increased health issues.