Long-range medical image registration through generalized mutual information (GMI): towards a fully automatic volumetric alignment.

Mutual information (MI) is consolidated as a robust similarity metric often used for medical image registration. Although MI provides a robust registration, it usually fails when the transform needed to register an image is too large due to MI local minima traps. This paper proposes and evaluates Generalized MI (GMI), using Tsallis entropy, to improve affine registration.