Publications by authors named "Vinh Khanh Doan"
Article Synopsis
- Current biofabrication methods struggle to mimic the complex relationships between the shapes and functions of engineered tissues due to limitations in hydrogels used.
- This study introduces a new microfluidics platform that allows for precise control over the structure and composition of hydrogels through a two-step process, enabling the creation of unique shapes, sizes, and stiffness patterns.
- The platform successfully encapsulates stem cells and demonstrates how variations in stiffness can influence cell behavior, with potential implications for breast cancer metastasis based on stiffness gradients.
A synergistic multilayer membrane design is necessary to satisfy a multitude of requirements of an ideal wound dressing. In this study, trilayer dressings with asymmetric wettability, composed of electrospun polycaprolactone (PCL) base membranes coated with oligomer chitosan (COS) in various concentrations of polyvinylpyrrolidone (PVP), are fabricated for wound dressing application. The membranes are expected to synergize the hygroscopic, antibacterial, hemostatic, and biocompatible properties of PCL and COS.
View Article and Find Full Text PDFThe use of naturally occurring materials with antibacterial properties has gained a great interest in infected wound management. Despite being an abundant resource in Vietnam, chitosan and its derivatives have not yet been intensively explored for their potential in such application. Here, we utilized a local chitosan source to synthesize chitosan oligomers (OCS) using hydrogen peroxide (HO) oxidation under the microwave irradiation method.
View Article and Find Full Text PDFArticle Synopsis
- This research focuses on creating and testing a new type of wound dressing made from an electrospun polycaprolactone (EsPCL) membrane enhanced with chitosan oligomers (COS) for better healing support.* -
- The study involved various experiments to assess the physical properties, antibacterial effectiveness, and compatibility of the membrane in both lab settings and in live mice models.* -
- Results indicated that higher concentrations of COS improved the membrane's thickness and antibacterial properties, promoted faster blood clotting, and positively influenced wound healing processes.*