[Significance of lacrimal fluid peroxidation and anti-radical defense parameters for prediction and treatment of complicated myopia].

Study of lipid peroxidation and antiradical defense parameters in the lacrimal fluid from 270 eyes of children and adolescents with progressive myopia demonstrated a relationship between the development of peripheral vitreochorioretinal dystrophies and imbalance between antioxidant activity (AOA) of lacrimal fluid and intensity of radical formation evaluated by chemiluminescence (CL) intensity. The AOA/CL ratio is proposed as a reliable indicator for predicting the course of progressive myopia. A value < 30 indicates poor level of antioxidant defense of ocular media and tissues and is a prognostically unfavorable sign as regards development of peripheral vitreochorioretinal dystrophy.

[Permeability of blood-eye barrier in patients with primary glaucoma combined with lens opacity].

The development of glaucoma involves changes in the chamber humor caused by hydrodynamic disorders. Primary glaucoma is often combined with lens opacities. Comparison of the content of protein and protein fractions in aqueous humor and blood serum of patients with glaucoma and different degree of lens opacity showed that, in contrast to senile cataract, cataract in a glaucomatous eye forms when the permeability of the blood-eye barrier is increased, which justifies the administration of drugs stabilizing it.

[Permeability of blood-aqueous humor barrier in primary open-angle glaucoma].

Biochemical changes in the chamber humor play an important role in the pathogenesis of primary open-angle glaucoma and are largely determined by the permeability of the blood-eye barrier. Comparative study of total protein content in the chamber humor in mature and far advanced glaucoma showed that the disease involves a progressive increase in the permeability of the blood-aqueous humor barrier, which may be due to dystrophic changes in ocular tissues in the course of glaucoma progress and accumulation of metabolites damaging the biological membranes in the chamber fluid or to antiglaucoma drugs increasing the permeability of the blood-humor barrier.

[Role of free radical oxidation reaction in lens opacities after antiglaucoma surgery].

The content of lipid peroxidation products (malonic dialdehyde) in the aqueous humor is increased in patients with mature cataracts developing after antiglaucoma surgery. Antioxidative activity of the humor was decreased. A relationship was revealed between the postoperative changes in ocular hydrodynamics and metabolic disorders in the chamber humor (reduction of the antioxidative activity of the humor and its suppressed production), which explains one mechanism of cataract development in patients operated on for glaucoma.

[Contribution of free-radical reactions of chamber humor to the development of primary open-angle glaucoma].

The level of lipid peroxidation products (malonic dialdehyde) is more than two times increased in the anterior chamber humor in patients with far advanced glaucoma in comparison with the well-developed stage. The level of the total antioxidant activity of humor is reliably lowered. A correlation has been revealed between the antioxidant activity of humor and its production.

[Study of lacrimal fluid trace elements in several eye diseases].

Trace element composition and content were studied by neutron activation method and atomic emission spectral analysis in 200 lacrimal fluid samples from children and adolescents with emmetropia and progressive myopia of 3.5 to 12.0 diopters and in 48 samples from adults with open-angle glaucoma, diabetic retinopathy, and without ocular diseases (controls).

[Copper metabolism in scleral tissue and possibilities of its correction in myopia].

Copper measurements in scleral tissue of 14 cadaveric emmetropic eyes and in 10 eyes with myopia of various degrees have shown a significant reduction of these levels in the equatorial and posterior segments of myopic sclera and abnormal distribution of copper in the tissue, this indicating disordered metabolism of this trace element. A method for drug correction of the detected disorder has been experimentally tried, consisting in administration under the Tenon's capsule of a copper coordination compound on a foam composition base, used for sclera-fortifying injections in progressive myopia. This resulted in elevation of scleral copper concentration, activization of collagen biosynthesis processes, and improvement of scleral tissue elasticity.

[Effect of antioxidants with different antiradical activity on cornea preservation].

Changes of chemoluminescence intensity, collagen mucopolysaccaride content in the rabbit eye cornea were studied on 32 cornea of shinshilla eye conservated by dehydration under hipotenia (2 divided by 4 degrees C) for 60 days with the application of antioxidants (tocoferol, chlorhydrate 2-ethyl, 6-methyl-3-oxipyridine) having different antiradical activity. It is concluded that the application of natural antioxidant alpha-tocoferol having high antiradical activity is expedient for the conservation of cornea.