Publications by authors named "Vineeta Jagana"

Article Synopsis
  • Idiopathic Pulmonary Fibrosis (IPF) is a lung disease characterized by progressive scarring and currently lacks a cure, prompting the need for new therapeutic targets such as the cAMP pathway, particularly the protein Epac1.* -
  • The study aimed to understand how Epac1 contributes to IPF progression by examining lung samples from IPF patients and preclinical models, alongside testing the effects of inhibiting Epac1 using a specific pharmacological agent, AM-001.* -
  • Results showed that Epac1 levels were elevated in IPF tissue and fibroblasts, and inhibiting Epac1 led to reduced fibroblast proliferation and profibrotic signaling, indicating its potential role as a therapeutic target
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Article Synopsis
  • Metabolic syndrome increases the risk of coronary artery disease and affects heart function, which was studied in female mice fed a Western diet compared to those on regular chow.
  • Mice on the Western diet showed increased body weight and left ventricular mass but maintained systolic and diastolic function, alongside reduced heart rate variability indicating altered cardiac balance.
  • Myocytes from these mice exhibited changes in size and mechanics, with heightened cAMP and PKA activity; interventions affecting this pathway improved their function, suggesting adaptations to maintain heart performance despite diet-induced metabolic issues.
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Epigenetic mechanisms, including DNA methylation, histone modifications, and non-coding RNA, play a crucial role in the regulation of gene expression and are pivotal in biological processes like apoptosis, cell proliferation, and differentiation. SIN3a serves as a scaffold protein and facilitates interactions with transcriptional epigenetic partners and specific DNA-binding transcription factors to modulate gene expression by adding or removing epigenetic marks. However, the activation or repression of gene expression depends on the factors that interact with SIN3a, as it can recruit both transcriptional activators and repressors.

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The space radiation (IR) environment contains high charge and energy (HZE) nuclei emitted from galactic cosmic rays with the ability to overcome current shielding strategies, posing increased IR-induced cardiovascular disease risks for astronauts on prolonged space missions. Little is known about the effect of 5-ion simplified galactic cosmic ray simulation (simGCRsim) exposure on left ventricular (LV) function. Three-month-old, age-matched male Apolipoprotein E (ApoE) null mice were irradiated with Cs gamma (γ; 100, 200, and 400 cGy) and simGCRsim (50, 100, 150 cGy all at 500 MeV/nucleon (n)).

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Pulmonary arterial hypertension (PAH) is a multifactorial disease associated with the remodeling of pulmonary blood vessels. If left unaddressed, PAH can lead to right heart failure and even death. Multiple biological processes, such as smooth muscle proliferation, endothelial dysfunction, inflammation, and resistance to apoptosis, are associated with PAH.

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