Conjugates of amphotericin B to resolve challenges associated with its delivery.

Introduction: Amphotericin B (AmB), a promising antifungal and antileishmanial drug, acts on the membrane of microorganisms. The clinical use of AmB is limited due to issues associated with its delivery including poor solubility and bioavailability, instability in acidic media, poor intestinal permeability, dose and aggregation state dependent toxicity, parenteral administration, and requirement of cold chain for transport and storage, etc.

Areas Covered: Scientists have formulated and explored various covalent conjugates of AmB to reduce its toxicity with increase in solubility, oral bioavailability, and payload or loading of AmB by using various polymers, lipids, carbon-based nanocarriers, metallic nanoparticles, and vesicular carriers, etc.

Application of a regional hurricane wind risk forecasting model for wood-frame houses.

Hurricane wind risk in a region changes over time due to changes in the number, type, locations, vulnerability, and value of buildings. A model was developed to quantitatively estimate changes over time in hurricane wind risk to wood-frame houses (defined in terms of potential for direct economic loss), and to estimate how different factors, such as building code changes and population growth, contribute to that change. The model, which is implemented in a simulation, produces a probability distribution of direct economic losses for each census tract in the study region at each time step in the specified time horizon.