Publications by authors named "Vincenzo Verdi"
Article Synopsis
- Microenvironmental factors play a key yet unclear role in the progression of soft tissue sarcomas, especially during their onset.
- A novel zebrafish model was developed to differentiate among microenvironmental, precancerous, and cancer cells, focusing on malignant peripheral nerve sheath tumors (MPNST), which grow aggressively.
- The study reveals that specific inflammatory signaling pathways are activated during the transition from precancerous to cancerous states, highlighting the role of macrophages and identifying periostin as a significant protein in MPNST progression.
Article Synopsis
- Multicellular organisms rely on intercellular communication to coordinate activities among various cell types, with a key mechanism being the exchange of extracellular vesicles (EVs).
- EVs are tiny lipid bilayer structures that carry biomolecules and facilitate communication over short and long distances between cells and their environment.
- The review discusses advances in imaging EVs in living organisms, highlighting zebrafish as an effective model for studying EV dynamics and understanding their role in biological processes.
Article Synopsis
- Acute or chronic guanosine (GUO) administration shows anxiolytic-like effects in rats, suggesting involvement of the adenosine (ADO) system, although direct evidence was lacking prior to this study.
- The study confirmed that GUO induces these effects; however, pretreatment with adenosine receptor (AR) agonists blocked the anxiolytic effects of GUO, indicating AR involvement.
- Binding assays further revealed potential GUO binding sites, where ADO displaced GUO binding more effectively than AR selective agonists, hinting at a complex interaction between GUO and ADO receptors.
Article Synopsis
- Oxotremorine (Oxo) enhances neuronal plasticity, potentially aiding in the treatment of anxiety and depression linked to chronic stress.
- The study tested Oxo's anxiolytic effects in rats subjected to chronic restraint stress, measuring behavior through various anxiety tests and assessing neurotrophic factor levels.
- Results indicated that Oxo treatment reduced anxiety and restored reduced levels of BDNF and FGF2 in key brain areas, suggesting its therapeutic potential for anxiety-related disorders.