Immune Dysfunction in Medication-Related Osteonecrosis of the Jaw.

The pathogenesis of medication-related osteonecrosis of the jaw (MRONJ) is multifactorial and there is a substantial consensus on the role of antiresorptive drugs (ARDs), including bisphosphonates (BPs) and denosumab (Dmab), as one of the main determinants. The time exposure, cumulative dose and administration intensity of these drugs are critical parameters to be considered in the treatment of patients, as cancer patients show the highest incidence of MRONJ. BPs and Dmab have distinct mechanisms of action on bone, but they also exert different effects on immune subsets which interact with bone cells, thus contributing to the onset of MRONJ.

Flexibility of Bayesian generalized linear mixed models for oral health research.

Many outcome variables in oral research are characterized by positive values and heavy skewness in the right tail. Examples are provided by many distributions of dental variables such as DMF (decayed, missing, filled teeth) scores, oral health impact profile score, gingival index scores, and microbiologic counts. Moreover, heterogeneity in data arises when more than one tooth is studied for each patient, due to the clusterization.

A new coping for overdentures. Part 1: A pilot study of the marginal precision.

The aim of this study was to investigate the marginal precision of new chairside copings prepared on 20 extracted teeth. The marginal fit was examined microscopically through 360-degree external observations. Subsequently, 10 new copings were adapted in vivo on 10 teeth that were planned for extraction.

Dimensional contour stability of acrylic resin bases for complete dentures before and after water sorption.

Purpose: To evaluate the dimensional contour variations of acrylic resin denture bases before and after storage in water.

Materials And Methods: The fit of 40 bases was evaluated by measuring the thickness of a layer made with silicone placed between the bases and the casts. The measurements were repeated on a new set of silicone layers after having stored the bases in water for 42 days.