Publications by authors named "Vincenzo Maione"
Objectives: Genital lichen sclerosus (LS) is a chronic mucocutaneous disorder causing considerable discomfort. Despite this, comprehensive comparison of LS impacts on quality of life (QoL), particularly on men's health or relative to other dermatological conditions like pemphigus, are sparse. This research aims to discern the effects of LS on sexual functionality and overall QoL, benchmarking against pemphigus patients and healthy controls.
View Article and Find Full Text PDFEosinophilic fasciitis (EF) poses a diagnostic challenge owing to its uncommon occurrence and aetiology that remains poorly understood. We report a case of a 79-year-old woman with a prolonged history of breast cancer exhibiting EF with concomitant pelvic metastases. This case underscores EF's potential as an indicator signaling a potential resurgence of cancer, highlighting its significance as a red flag of disease recurrence.
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- Pemphigus is an autoimmune disorder that negatively affects patients' quality of life, particularly their sleep quality, which has been under-researched.
- A study with 156 participants found that those with pemphigus reported higher psychological distress and significantly poorer sleep quality compared to a control group, with specific sleep issues correlated to the severity of their condition.
- The research highlights the importance of considering sleep quality in the overall management of pemphigus, especially since patients with skin manifestations experienced worse sleep than those with oral symptoms.
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- Porokeratosis variants are uncommon skin conditions that can often be misdiagnosed, mimicking more common skin issues.
- A new technology called line-field confocal optical coherence tomography (LC-OCT) allows for non-invasive imaging of the skin, providing detailed views up to 500µm deep.
- In a study with 54 patients, LC-OCT showed high reliability in diagnosing porokeratosis variants and identified unique features not visible in traditional histology, suggesting it could help avoid unnecessary biopsies.
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- Genital psoriasis affects about 60% of psoriasis patients, presenting challenges in treatment, but IL-17 inhibitors like bimekizumab have shown promise for this difficult condition.
- A 16-week study on 65 participants revealed that 98.4% achieved clear improvement in genital psoriasis, demonstrating both effective symptom relief and enhanced quality of life.
- The results indicate bimekizumab could be a beneficial treatment for genital psoriasis, but further research with larger and longer studies is needed to confirm these findings.
Article Synopsis
- Bimekizumab, a monoclonal antibody targeting Interleukin-17 A and F, is effective for moderate-to-severe plaque psoriasis, though real-world data is limited.
- A retrospective study in 19 Italian hospitals assessed 237 patients treated with bimekizumab, measuring psoriasis severity at 4 and 16 weeks based on PASI scores.
- Results showed significant improvements in skin clearance and quality of life, with 75.4% achieving clear skin by week 16, and side effects were minimal and manageable.
Background: The detection of subclinical margin in lentigo maligna/lentigo maligna melanoma (LM/LMM) can be challenging for the dermatologist. Reflectance confocal microscopy (RCM) enables to observe in vivo atypical melanocytes beyond the clinical margins. The aim of this study is to establish which of these methods (clinical examination and dermoscopy versus "Paper tape - RCM") is more precise to define the lesion margin and to reduce the number of re-intervention and overtreatments in cosmetically sensitive areas.
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