Publications by authors named "Vincenzo Lamonaca"
Aim: To evaluate radiofrequency thermal ablation (RTA) for treatment of cystic echinococcosis in animal models (explanted organs).
Methods: Infected livers and lungs from slaughtered animals, 10 bovine and two ovine, were collected. Cysts were photographed, and their volume, cyst content, germinal layer adhesion status, wall calcification and presence of daughter or adjacent cysts were evaluated by ultrasound.
Article Synopsis
- Lamivudine therapy can temporarily boost antiviral T cell responses in chronic hepatitis B patients, but this increase isn't long-lasting.
- A study involving 12 patients monitored their HBV-specific CD4 and CD8 T cells over time, revealing an initial rise in their activity followed by a decline after about 5-6 months of treatment.
- Findings suggest that early therapeutic targeting of T cell responses is important, as the temporary nature of the immune boost could lead to virus reactivation once treatment ends.
Article Synopsis
- The study compared the functionality of CD4+ T cells specific to hepatitis C virus (HCV) from both blood and liver of 29 chronic HCV patients.
- Different HCV proteins were tested for their ability to stimulate T-cell responses, with the core protein being the most recognized by intrahepatic T cells.
- Although the immune response was focused on a few key protein sections, no escape mutations were detected over time, indicating a strong and stable immune response in the liver.