Publications by authors named "Vincenzo Centonze"
Excessive and uncontrolled oxidative stress can damage biomacromolecules, such as lipids, proteins, carbohydrates, and DNA, by free radical and oxidant overproduction. In this review, we critically discuss the main properties of free radicals, their implications in oxidative stress, and specific pathological conditions. In clinical medicine, oxidative stress can play a role in several chronic noncommunicable diseases, such as diabetes mellitus, cardiovascular, inflammatory, neurodegenerative diseases, and tumours.
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- Aging involves a gradual decline in tissue and organ function influenced by genetics, environment, nutrition, and lifestyle, with oxidative stress playing a key role in cellular aging and frailty.
- Several factors contribute to aging, including genomic instability, telomere shortening, and mitochondrial dysfunction, all of which can be affected by diet and lifestyle choices.
- Nutritional strategies such as the Mediterranean diet, dietary antioxidants, and caloric restriction show potential for promoting healthy aging and could lead to new biomarkers and treatments aimed at extending lifespan.
Authors discuss therapeutic potential of reading activity, partially still unknown. Starting from Menninger's work in the early 30's until most recent studies from Frude, Berns, Comer who confirmed its efficacy in both the so-called non-organic diseases and chronic pathological conditions. Their studies strongly suggested psychobiological mechanisms through which reading activity exerts its therapeutic effects.
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