Deregulation of New Cell Death Mechanisms in Leukemia.

Hematological malignancies are among the top five most frequent forms of cancer in developed countries worldwide. Although the new therapeutic approaches have improved the quality and the life expectancy of patients, the high rate of recurrence and drug resistance are the main issues for counteracting blood disorders. Chemotherapy-resistant leukemic clones activate molecular processes for biological survival, preventing the activation of regulated cell death pathways, leading to cancer progression.

First validation of the technical and administrative staff quality of life at work tool (TASQ@work) in academia.

Introduction: Based on the job demands-resources (JD-R) model, the present study aimed to validate "The Technical and Administrative Staff Quality of Life At Work" (TASQ@work), a new tool to assess the quality of life at work in academia focused on technical and administrative staff.

Methods: This tool was developed by the QoL@Work research team, a group of expert academics in the field of work and organizational psychology affiliated with the Italian Association of Psychologists. The TASQ@work was elaborated in different steps.

Psychosocial factors contributing to value creation in value-based healthcare: a scoping review.

Background: Healthcare systems constantly evolve to improve care quality and resource utilization. One way is implementing Value-Based Healthcare (VBHC) an economic approach. This scoping review aims to identify and describe the literature on VBHC, particularly its psychosocial aspects, to uncover research gaps.

Involvement of regulated cell deaths in aging and age-related pathologies.

Aging is a pathophysiological process that causes a gradual and permanent reduction in all biological system functions. The phenomenon is caused by the accumulation of endogenous and exogenous damage as a result of several stressors, resulting in significantly increased risks of various age-related diseases such as neurodegenerative diseases, cardiovascular diseases, metabolic diseases, musculoskeletal diseases, and immune system diseases. In addition, aging appears to be connected with mis-regulation of programmed cell death (PCD), which is required for regular cell turnover in many tissues sustained by cell division.

The new normal of remote work: exploring individual and organizational factors affecting work-related outcomes and well-being in academia.

Background: Flexible work arrangements have become increasingly popular, driven by the widespread adoption of digital technologies in the workplace because of the pandemic. However, there is a scarcity of studies concerning remote work, especially related to technical-administrative staff (TAS) in academia. Therefore, the current study, adopting the Job Demands-Resources model, aimed to investigate the relationships between remote working self-efficacy, organizational support, techno-complexity, mental well-being, and job performance among TAS during remote working.

Value of Care: An Exploratory Qualitative Study with Doctors and Patients.

The concept of value in healthcare is mainly based on economic and financial aspects. However, the literature has emphasised the need to investigate value from other perspectives. The present study aimed to explore the views of physicians and patients on the value of healthcare, and to examine in depth the psychosocial and organisational elements that have emerged but that need to be investigated more.

HAT1: Landscape of Biological Function and Role in Cancer.

Histone modifications, as key chromatin regulators, play a pivotal role in the pathogenesis of several diseases, such as cancer. Acetylation, and more specifically lysine acetylation, is a reversible epigenetic process with a fundamental role in cell life, able to target histone and non-histone proteins. This epigenetic modification regulates transcriptional processes and protein activity, stability, and localization.

Ageism and the Pandemic: Risk and Protective Factors of Well-Being in Older People.

The COVID-19 pandemic has particularly affected the older population both in terms of the high number of victims and the psychological impact. Moreover, the pandemic has made older people more vulnerable to isolation and loneliness, and victims of ageism. The aim of the present study was to investigate the risk and protective factors for the well-being of older people during the pandemic.

Job Satisfaction Mediates the Relationship between Psychosocial and Organization Factors and Mental Well-Being in Schoolteachers.

The study aimed to explore the associations between the psychosocial and organizational factors, job satisfaction, and mental well-being of schoolteachers. A further aim was to examine whether job satisfaction mediated the relationship between these factors and mental well-being. A cross-sectional design was used to collect data using a self-reported questionnaire.

Learning Design Strategies in MOOCs for Physicians' Training: A Scoping Review.

In recent years, there has been an increased implementation of massive open online courses (MOOCs). This teaching model plays a pivotal role in online education because it can provide high-quality learning resources to numerous students with great feasibility, shaping training courses according to their different learning requirements. Although the widespread adoption of MOOCs in medical education has led to numerous benefits for undergraduate and graduate doctors, their role remains unclear, suggesting the need to analyze the key factors of such a learning method in this field.

Technology-Enhanced Learning and Well-being: a Contribution to the Validation of a Measure to Assess University Students' Technostress in the Italian Context.

COVID-19 has forced many universities to adopt widely technology-enhanced learning (TEL), highlighting the role of technostress as a risk factor for detrimental outcomes that may be prevented through the assessment with reliable tools. Thus, the present study aimed to test the psychometric characteristics of the Italian validation of the technostress scale by Wang, Tan, and Li. A self-report online questionnaire was completed by 915 participants (aged 18-33 years) attending an online university course during the health emergency.

Medical Communication Perceived Self-Efficacy (ME-CO) Scale: Construction and Validation of a New Measuring Instrument from a Socio-Cognitive Perspective.

The study presents the validation of a scale measuring physicians' efficacy beliefs about their ability to manage issues related to communication with patients. Specifically, the tool focused on three fundamental phases of the clinical interview: collecting information, returning information to patients, and creating and maintaining a relationship with them. The research included two studies.

Mental Well-Being and Job Satisfaction of Hospital Physicians during COVID-19: Relationships with Efficacy Beliefs, Organizational Support, and Organizational Non-Technical Skills.

The COVID-19 outbreak has led worldwide governments to take preventive measures to contain the spread of the virus and its extraordinary demands upon healthcare workers. Consequently, healthcare workers have been under high pressures, putting them at risk of developing adverse outcomes. The present study aims to investigate the psychological and organizational factors that contributed to physicians' well-being during the pandemic.

A New Academic Quality at Work Tool (AQ@workT) to Assess the Quality of Life at Work in the Italian Academic Context.

The present study provides evidence for a valid and reliable tool, the Academic Quality at Work Tool (AQ@workT), to investigate the quality of life at work in academics within the Italian university sector. The AQ@workT was developed by the QoL@Work research team, namely a group of expert academics in the field of work and organizational psychology affiliated with the Italian Association of Psychologists. The tool is grounded in the job demands-resources model and its psychometric properties were assessed in three studies comprising a wide sample of lecturers, researchers, and professors: a pilot study (N = 120), a calibration study (N = 1084), and a validation study (N = 1481).

Perceived Employability, Academic Commitment, and Competency of University Students During the COVID-19 Pandemic: An Exploratory Study of Student Well-Being.

Coronavirus disease 2019 (COVID-19) outbreak has led to the closure of schools and universities, which forced students to reorganize their daily and academic lives. The pandemic has thus impacted the well-being of students in various ways. This study aimed to investigate the relationship between the perceived employability, self-efficacy, ambition, organizational commitment, and career planning of students, as well as mental well-being, student engagement, and academic burnout during the pandemic.

Smart Working and Well-Being before and during the COVID-19 Pandemic: A Scoping Review.

The purpose of this scoping review focused on the relationship between smart working, a conception of job centered on the flexibility and autonomy of the worker, and well-being/illness in an organizational context before and during COVID-19. The literature review, conducted using the PRISMA (Preferred Reporting Items for Systematic Review and Meta-Analysis for qualitative synthesis) method for qualitative synthesis, considered studies published from 2014 to 2020. From the analyses conducted by three independent coders, three main areas of interest in the literature emerged: (1) smart working and work engagement, (2) smart working and technostress, and (3) mediators of the relationship between smart working and well-being.

Validation and Psychometric Evaluation of the COVID-19 Risk Perception Scale (CoRP): a New Brief Scale to Measure Individuals' Risk Perception.

The aim of the work was to develop and validate the COVID-19 Risk Perception Scale (CoRP), a brief self-report questionnaire for individuals' perceptions of risk in the COVID-19 pandemic. Two studies were conducted in order to evaluate the new scale's psychometric properties. Study 1 included 269 Italian participants (77.

The English Version of the Health Profession Communication Collective Efficacy Scale (HPCCE Scale) by Capone and Petrillo, 2012.

Communication is a crucial component in all steps of the health care process. Therefore, it is important to have knowledge about the communication skills of the whole health organization. From the socio-cognitive perspective, collective efficacy beliefs are the main indicators of the capacity of functioning of the system.

Efficacy Beliefs, Empowering Leadership, and Project Success in Public Research Centers: An Italian-Polish Study.

In the world of university research, although the figure of project manager is not formally foreseen, the principal researcher (PR) is, at many times, the last responsible the project results, schedule, and cost. The study aimed to investigate, in the light of the literature and through a cross-cultural study conducted in Italy and Poland, the relationship between soft skills (empowering leadership style, self-efficacy beliefs, and collective efficacy) of the principal researcher (PR) and the perceived success of research projects and satisfaction with the project, taking into account cross-cultural differences. A total of 67 PRs of complex projects in public universities (28 in Italy and 39 in Poland) participated in the study, completing a self-report questionnaire.

Working during a Pandemic between the Risk of Being Infected and/or the Risks Related to Social Distancing: First Validation of the SAPH@W Questionnaire.

Background: The COVID-19 pandemic led the worldwide healthcare system to a severe crisis in which personnel paid the major costs. Many studies were promptly dedicated to the physical and psychological consequences of the COVID-19 exposure among healthcare employees, whereas the research on the other working populations has been substantially ignored. To bridge the current lack of knowledge about safe behaviors related to the risk of COVID-19 contagion at work, the aim of the study was to validate a new tool, the SAPH@W (Safety at Work), to assess workers' perceptions of safety.

Validation of the Chinese Version of the Patient's Communication Perceived Self-Efficacy Scale (PCSS) in Outpatients After Total Hip Replacement.

Background: Among older people in the world, older patients' communication has become a public health issue of vital importance. Such communication could be improved by different interventions. However, a means of measuring patient's communication confidence in these measures has not been established in China.

Five Dimensions of European Identity: A Contribution to the Italian Adaptation and Validation of the In-Group Identification Scale.

Recent approaches define collective identity as a multi-component construct. Nonetheless, there is a lack of research about the dimensionality of in-group identification in relation to European Identity. Leach and colleagues (2008) proposed a framework of in-group identification, in which they distinguish five main components integrated into two higher-order dimensions.

Patient communication self-efficacy, self-reported illness symptoms, physician communication style and mental health and illness in hospital outpatients.

In this cross-sectional study, we investigated the associations between patient communication self-efficacy and self-reported symptoms in doctor-patient communication, as perceived by patients, and the mental health and illness of hospital outpatients. Using data from a sample of 74 outpatients (mean age = 37.58 years, standard deviation = 12.

Patient's Communication Perceived Self-efficacy Scale (PCSS): construction and validation of a new measure in a socio-cognitive perspective.

Objective: In two studies we constructed and validated the Patient's Communication Perceived Self-efficacy Scale (PCSS) designed to assess patients' beliefs about their capability to successfully manage problematic situations related to communication with doctor.

Methods: The 20-item scale was administered to 179 outpatients (study 1). An Exploratory Factor Analysis revealed a three-factor solution.