Publications by authors named "Vincent le Moing"
Introduction: HIV replication leads to a change in lymphocyte phenotypes that impairs immune protection against opportunistic infections. We examined current HIV replication as an independent risk factor for tuberculosis (TB).
Methods: We included people living with HIV from 25 European cohorts 1983-2015.
Background: Liver transplant recipients are at risk of tuberculosis, which is particularly difficult-to diagnose and to treat in this population.
Methods: Retrospective study of all cases of tuberculosis diagnosed from 2007 to 2022 in the French network of liver transplant sites.
Results: Twenty-three liver transplant recipients were diagnosed with tuberculosis (six females, median age 59 years [interquartile range, 54-62]), with a median time lapse of 10 months [5-40.
Compared Performance of the 2023 Duke-International Society for Cardiovascular Infectious Diseases, 2000 Modified Duke, and 2015 European Society of Cardiology Criteria for the Diagnosis of Infective Endocarditis in a French Multicenter Prospective Cohort.
Clin Infect Dis
April 2024
Article Synopsis
- The 2023 Duke-ISCVID criteria for diagnosing infective endocarditis (IE) were tested against the previous 2000 Modified Duke and 2015 ESC criteria using a large patient cohort treated for the condition.
- A total of 1194 patients were analyzed, revealing that the 2023 criteria had the highest sensitivity (97.6%) but the lowest specificity (46.0%) compared to the other criteria.
- The lower specificity in the 2023 criteria was largely due to the inclusion of patients with cardiac implanted electronic devices (CIED), highlighting the need for cautious interpretation in this group.
The early administration of appropriate antibiotic therapy is crucial for the survival of patients with bacteremia. Current research focuses on improving analytical times through technology, whereas there have been very few efforts to improve postanalytical times even though they represent 40% of the time between blood taking and appropriate treatment administration. One of the clues is the efficiency and appropriateness of the result communication system.
View Article and Find Full Text PDFObjective: Cerebral vasculitis (CV) is a severe complication of pneumococcal meningitis (PM); whether dexamethasone use can reduce its occurrence remains to be determined.
Methods: This is a retrospective observational bicentric study analyzing all adults with proven PM hospitalized between January 2002 and December 2020 in two tertiary hospitals. Extrapolating from a standardized definition of primary angiitis of the central nervous system, we defined CV as worsened neurological symptoms associated with compatible imaging.
Effect of weight-adjusted intermediate-dose versus fixed-dose prophylactic anticoagulation with low-molecular-weight heparin on venous thromboembolism among noncritically and critically ill patients with COVID-19: the COVI-DOSE trial, a multicenter, randomised, open-label, phase 4 trial.
EClinicalMedicine
June 2023
Background: Venous thromboembolism is a major complication of coronavirus disease 2019 (COVID-19). We hypothesized that a weight-adjusted intermediate dose of anticoagulation may decrease the risk of venous thromboembolism COVID-19 patients.
Methods: In this multicenter, randomised, open-label, phase 4, superiority trial with blinded adjudication of outcomes, we randomly assigned adult patients hospitalised in 20 French centers and presenting with acute respiratory SARS-CoV-2.
Objectives: The objective of this prospective, single-center study was to explore the mid-term outcomes 6 to 9 months after hospitalization in an Intensive Care Unit (ICU) for severe COVID-19 infection.
Methods: Patients systematically underwent biological tests, pulmonary function tests, chest computed tomography (CT) scan, and psychological tests.
Results: Among 86 patients, including 71 (82.
Objectives: We aimed at determining whether specific S. aureus strains cause infective endocarditis (IE) in the course of Staphylococcus aureus bacteraemia (SAB).
Methods: A genome-wide association study (GWAS) including 924 S.
Article Synopsis
- The study aimed to identify new prognostic factors that could predict outcomes in Staphylococcus aureus infective endocarditis (SaIE), which has a high mortality rate.
- Researchers reviewed medical records of 30 patients and found 56 candidate prognostic factors, ultimately narrowing it down to three significant factors: prior use of NSAIDs, non-performance of valve surgery when needed, and decrease in vegetation size on antibiotic treatment.
- If confirmed in further studies, these factors could enhance patient management and potentially lower the lethality associated with SaIE.
Objectives: Severe trauma patients are at higher risk of infection and often exposed to antibiotics, which could favor acquisition of antimicrobial resistance. In this study, we aimed to assess prevalence, acquisition, and factors associated with acquisition of extended-spectrum cephalosporin-resistant Gram-negative bacteria (ESCR-GNB) in severe trauma patients.
Methods: We conducted a retrospective monocentric cohort study in a French level one Regional Trauma Centre between 01 January 2010and 31 December 2015.
Population-based data on the epidemiology of progressive multifocal leukoencephalopathy, its predisposing conditions and mortality rate are lacking, although such data are crucial to raise awareness among clinicians and to lay foundations for future therapeutic trials in immunomodulating therapies. In our study, patients were identified by interrogating the French national healthcare reimbursement database from 1 January 2008 to 31 December 2017, using progressive multifocal leukoencephalopathy International Classification of Diseases code and a patient's selection algorithm. Overall incidence rate, 1-year all-cause mortality rate and survival patterns were calculated, and factors associated with death were identified using a multivariate Cox proportional hazards regression model.
View Article and Find Full Text PDFArticle Synopsis
- Lymphopenia, a condition where lymphocyte (a type of white blood cell) levels are low, is often found in sepsis patients and is linked to higher mortality rates.
- The study examined if lymphopenia could be a reliable indicator of outcomes in patients with bacteremia, involving 574 individuals from two hospitals.
- Results showed that initial lymphocyte counts and changes over the first four days did not predict 12-week mortality, suggesting the need for a better understanding of each patient’s immune profile before pursuing immune therapies.
Article Synopsis
- The study aimed to analyze patients with both infective endocarditis (IE) and bacterial meningitis (BM), merging data from two large cohorts to explore their characteristics.
- Out of 1030 patients, 42 had both conditions, with meningitis being the primary admission presentation and the most common pathogens identified as Streptococcus pneumoniae and Staphylococcus aureus.
- The findings indicate that patients with this dual infection have a higher mortality rate compared to those with only IE or BM, highlighting the need for early diagnosis and treatment.
Article Synopsis
- SARS-CoV-2 nucleocapsid antigen (N-Ag) can be found in the urine of COVID-19 patients, indicating a potential indicator of disease severity.
- A study involving 82 patients showed high levels of urinary N-Ag during the first two weeks of infection, with significant correlations to severe clinical features, like ICU admission and abnormal blood markers.
- The findings suggest that urinary N-Ag could serve as a more accurate predictor of severe COVID-19 compared to plasma N-Ag, highlighting its possible use in clinical assessments.
Objective: Since 2002, France has adopted the Patients' Rights Law, an alternative malpractice scheme creating a faster, less expensive out-of-court settlement ensuring compensation even in the absence of fault. We aimed to describe the implications of this system by analyzing 5 years of claims for infections related to spinal surgeries collected by the main insurer of French spine surgeons.
Methods: We retrospectively analyzed 98 anonymized malpractice claims from 2015 to 2019 (20% of overall claims), including anonymized medical records of the patients, reports of the independent experts, final judgments, and entities supporting the compensation if any.
Objective: To explore the diagnostic contribution of the F-FDG-PET/CT in a population of patients with classical fever of unknown origin (FUO), to pinpoint its place in the diagnostic decision tree in a real-life setting, and to identify the factors associated with a diagnostic F-FDG-PET/CT.
Method: All adult patients (aged ≥ 18 years) with a diagnosis of classical FUO who underwent an F-FDG-PET/CT in the University Hospital of Montpellier (France) between April 2012 and December 2017 were included. True positive F-FDG-PET/CT, which evidenced a specific disease causing FUO, were considered to be contributive.
Background: We ascertained incidence of opportunistic infections (OIs) in people with human immunodeficiency virus (PWH) with cancer undergoing chemotherapy with non-human immunodeficiency virus (HIV) comparators.
Methods: We identified 2106 PWH and 2981 uninfected Veterans with cancer who received at least 1 dose of chemotherapy between 1996 and 2017 from the Veterans Aging Cohort Study. We ascertained incident OIs within 6 months of chemotherapy amongst zoster, cytomegalovirus, tuberculosis, esophagitis, pneumonia (PCP), toxoplasmosis, Cryptococcosis, atypical infection, bacteremia, histoplasmosis, coccidioidomycosis, or progressive multifocal leukoencephalopathy.
Background: A persistently low CD4/CD8 ratio has been reported to inversely correlate with the risk of non-AIDS defining cancer in people living with human immunodeficiency virus (HIV; PLWH) efficiently treated by combination antiretroviral therapy (cART). We evaluated the impact of the CD4/CD8 ratio on the risk of Kaposi sarcoma (KS) or non-Hodgkin lymphoma (NHL), still among the most frequent cancers in treated PLWH.
Methods: PLWH from the Collaboration of Observational HIV Epidemiological Research Europe (COHERE) were included if they achieved virological control (viral load ≤ 500 copies/mL) within 9 months following cART and without previous KS/LNH diagnosis.