Trans-Sclera Electrical Stimulation Improves Retinal Function in a Mouse Model of Retinitis Pigmentosa.

Retinitis pigmentosa (RP) is a photoreceptor-degenerating disease with no effective treatment. Trans-corneal electrical stimulation has neuroprotective effects in degenerating retinas, but repeated applications cause corneal injury. To avoid the risk of corneal damage, here we tested whether repetitive trans-sclera electrical stimulation (TsES) protects degenerating retinas in rd10 mice, a model of RP.

Electrical stimulation at nanoscale topography boosts neural stem cell neurogenesis through the enhancement of autophagy signaling.

Neural stem cells (NSCs) transplantation at the injury site of central nerve system (CNS) makes it possible for neuroregeneration. Long-term cell survival and low proliferation, differentiation, and migration rates of NSCs-graft have been the most challenging aspect on NSCs application. New multichannel electrical stimulation (ES) device was designed to enhance neural stem cells (NSCs) differentiation into mature neurons.

Using Electrical Stimulation to Enhance the Efficacy of Cell Transplantation Therapies for Neurodegenerative Retinal Diseases: Concepts, Challenges, and Future Perspectives.

Disease or trauma-induced loss or dysfunction of neurons in any central nervous system (CNS) tissue will have a significant impact on the health of the affected patient. The retina is a multilayered tissue that originates from the neuroectoderm, much like the brain and spinal cord. While sight is not required for life, neurodegeneration-related loss of vision not only affects the quality of life for the patient but also has societal implications in terms of health care expenditure.

Effect of optical zone ablation diameter on LASIK-induced higher order optical aberrations.

Purpose: To compare the postoperative higher order aberrations among eyes that had received conventional laser in situ keratomileusis (LASIK) treatment at different optical zone diameters using the Alcon LADARVision 4000 platform (Alcon, Ft Worth, Tex).

Methods: Monochromatic wavefront aberrations at 6.5-mm pupil size of 96 eyes of 96 Hong Kong Chinese patients with normal myopic astigmatism were objectively measured using the Alcon LADARWave aberrometer before and after (at least 6 months) conventional LASIK with the Autonomous LADARVision 4000 excimer laser.

Effectiveness of no-rub contact lens cleaning on protein removal: a pilot study.

Purpose: To compare the amount of protein deposits adhering to human-worn soft contact lenses, using the untreated contact lens from the contralateral eye as controls, to investigate the capabilities of the No Rub contact lens cleaning systems in protein removal from soft contact lenses.

Methods: New 1 Day Acuvue soft contact lenses were worn on a daily-wear basis by 16 Hong Kong Chinese volunteers on 5 separate days. Four right lenses of each subject were treated with No Rub contact lens cleaning systems (Alcon Opti-Free Express, Alcon Opti-Free Express No Rub Lasting Comfort Formula, B and L ReNu MultiPlus, and Ciba Vision SOLO Care Plus).

Retinal nerve fiber loss in high- and normal-tension glaucoma by optical coherence tomography.

Purpose: To compare the pattern of retinal nerve fiber layer (RNFL) damages in high-tension and normal-tension primary chronic open-angle glaucoma using optical coherence tomography (OCT).

Methods: Age- and refractive error-matched patients with normal-tension glaucoma (NTG) (n = 38) and high-tension glaucoma (HTG) (n = 48) and normal subjects (n = 48) were recruited. All subjects underwent complete eye examinations and OCT RNFL assessments.

Increasing scans per examination improves the reproducibility on retinal nerve fiber layer measurements by optical coherence tomography.

Purpose: To investigate whether increasing the number of scans per examination would improve the reproducibility of retinal nerve fiber layer (RNFL) measurements by optical coherence tomography (OCT) in healthy and glaucomatous eyes.

Methods: A total of 28 eyes of 28 healthy subjects and 20 eyes of 20 patients with primary chronic open-angle glaucoma were recruited. OCT RNFL assessments were obtained in one randomly selected eye.

Retinal nerve fiber loss pattern in high-tension glaucoma by optical coherence tomography.

Purpose: To identify the pattern of retinal nerve fiber layer thinning in high-tension primary chronic open-angle glaucoma (HT-PCOAG) using optical coherence tomography.

Methods: Retinal nerve fiber layer thickness was assessed with optical coherence tomography in 68 healthy controls and 68 age- and refractive error-matched patients with HT-PCOAG were recruited. Patients were divided into 3 subgroups according to their visual field mean deviation: early (> -3 dB), moderate (-3 to -7 dB), and moderately advanced (-7 to -15 dB).

Retinal nerve fiber layer measurement by optical coherence tomography in glaucoma suspects with short-wavelength perimetry abnormalities.

Purpose: To compare retinal nerve fiber layer (RNFL) measurements in normal and glaucoma subjects with short-wavelength automatic perimetry (SWAP) abnormalities and in chronic primary open-angle glaucoma (CPOAG) patients using optical coherence tomography (OCT).

Methods: Forty-eight eyes of normal subjects, 34 eyes of glaucoma suspects with SWAP abnormalities, and 38 eyes of early CPOAG subjects were recruited. All normal and glaucoma suspects had normal conventional automated perimetry visual field results.

Retinal nerve fiber layer measurement of the Hong Kong chinese population by optical coherence tomography.

Purpose: To obtain retinal nerve fiber layer (RNFL) measurements by optical coherence tomography in a local, normal Hong Kong Chinese population and to identify the correlation of the measurement with age cross-sectionally.

Methods: A total of 129 normal Hong Kong Chinese volunteers of different age groups were recruited for this study. The RNFL was measured by optical coherence tomography (OCT; OCT 2000; Humphrey Instruments, San Leandro, CA).

Disc-to-macula distance to disc-diameter ratio for optic disc size estimation.

Purpose: To investigate the usefulness of the parameter of disc-to-macula distance (DM) to disc-diameter (DD) ratio in estimating optic disc size.

Patients And Methods: A total of 88 normal subjects, 18 subjects with physiological macrodiscs, and 16 early glaucomatous patients were recruited for the study. The DM, which is the horizontal distance between the center of the optic disc and the macula, and DD were determined by planimetry.