Publications by authors named "Vincent Wai-Sun Wong"
Article Synopsis
- * The study collected and analyzed 1,600 posts from various countries, revealing that the most common topics included patients' journeys (92%), comorbidities (38%), and their interactions with healthcare professionals (26%).
- * Major findings indicated that unhealthy diets and obesity are significant risk factors, with fatigue and abdominal pain being prevalent symptoms; meanwhile, the disease has a considerable negative impact on patients' quality of life, especially for those with comorbidities and more severe conditions.
Background & Aims: Current international guidelines recommend close monitoring and evaluation of patients with chronic hepatitis B (CHB) in the indeterminate phase, and treatment of patients at high risk of adverse outcomes. Clinical outcomes and the effect of antiviral therapy on the indeterminate phase remain unclear. We performed a systematic review and meta-analysis to study the incidence of adverse clinical outcomes including hepatocellular carcinoma (HCC), cirrhosis, and hepatic decompensation, and the effect of antiviral therapy, in the indeterminate phase.
View Article and Find Full Text PDFWith the rising epidemic of obesity, metabolic syndrome, and type 2 diabetes mellitus in China, metabolic dysfunction-associated non-alcoholic fatty liver disease has become the most prevalent chronic liver disease. This condition frequently occurs in Chinese patients with alcoholic liver disease and chronic hepatitis B. To address the impending public health crisis of non-alcoholic fatty liver disease and its underlying metabolic issues, the Chinese Society of Hepatology and the Chinese Medical Association convened a panel of clinical experts to revise and update the "Guideline of prevention and treatment of non-alcoholic fatty liver disease (2018, China)".
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- - MASLD, previously known as NAFLD, can affect people with normal body weight, splitting into two categories: lean MASLD (with cardiometabolic risk factors) and cryptogenic steatotic liver disease (without these factors).
- - Research shows that the PNPLA3 rs738409 genetic variant is more prevalent in individuals with lean NAFLD compared to those who are overweight or obese, but cardiometabolic risk factors usually still play a role in liver issues.
- - Although the PNPLA3 gene is linked to severe liver conditions and complications, its specific effects on lean individuals with NAFLD have not been thoroughly investigated.
Gamma-glutamyl transferase: A potential biomarker for pancreas steatosis in patients with concurrent obesity, insulin resistance and metabolic dysfunction-associated steatotic liver disease.
Clin Obes
October 2024
To evaluate the relationship between serum gamma-glutamyl transferase (GGT) levels and fatty pancreas in subjects with concurrent obesity, insulin resistance and metabolic dysfunction-associated steatotic liver disease (MASLD) without a history of pancreatitis. From March 2019 to September 2021, 31 adult subjects with concurrent obesity and MASLD were recruited as part of the study investigating the biological impact of bariatric surgery and lifestyle modification on obesity. Chemical shift encoded MRI of the abdomen, LiverMultiScan, anthropometric, clinical and blood biochemistry analyses were performed prior to any intervention at baseline.
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- Scientists studied a health problem called MASH, which affects people's livers, and worked on two tests to help doctors tell if someone has it.
- They looked at data from over 3,000 people to make sure their first test, called acMASH, worked well, and then created a new test called acFibroMASH to find more severe cases.
- The new acFibroMASH test was better at predicting who might have future liver problems compared to another test, showing it's a useful tool for doctors to keep patients healthy.
Article Synopsis
- Direct-acting antivirals (DAAs) have improved treatment for chronic hepatitis C (HCV), but there is a lack of focus on the risk of liver-related events (LREs) after achieving sustained virological response (SVR), which this study aims to address with the AI-Safe-C score.
- The AI-Safe-C score, developed using data from 913 non-cirrhotic HCV patients, assesses the risk of LREs by considering factors like liver stiffness measurement (LSM), age, and sex, showing high prediction accuracy in validation cohorts from Korea, Hong Kong, and France.
- This score is essential for identifying non-cirrhotic patients at risk of developing LREs
Article Synopsis
- - The study aimed to create and validate a prognostic model for assessing the risk of hepatocellular carcinoma (HCC) in noncirrhotic adults with chronic hepatitis B, focusing on those without significant alanine aminotransferase (ALT) elevation.
- - Researchers analyzed data from over 13,000 patients across several cohorts in Taiwan, Korea, and Hong Kong, finding that baseline HBV DNA levels were key predictors of HCC risk, especially at moderate viral loads.
- - The new model, called Revised REACH-B, showed strong predictive accuracy and was more beneficial compared to other strategies in predicting HCC risk, though its applicability to other racial groups remains a limitation.
The role of dietary modification in the prevention and management of metabolic dysfunction-associated fatty liver disease: An international multidisciplinary expert consensus.
Metabolism
December 2024
Article Synopsis
- Metabolic dysfunction-associated fatty liver disease (MAFLD) is a rising cause of chronic liver disease globally, prompting the need for dietary intervention strategies.
- A panel of 55 international experts conducted a study to reach a consensus on dietary modifications for preventing MAFLD, covering various aspects from epidemiology to management.
- Recommended strategies include following a balanced diet, increasing whole grains and plant-based foods, and reducing red meat and processed foods, along with advocating for physical activity and possibly maintaining Mediterranean or DASH diets.
Enhanced liver fibrosis (ELF) score is a noninvasive assessment for liver fibrosis. We aimed to evaluate the performance of changes in ELF score 3 years apart in combination with liver stiffness measurement (LSM)-hepatocellular carcinoma (HCC) score to predict HCC in chronic hepatitis B (CHB) patients. This is a prospective cohort study.
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- * Researchers analyzed data from nearly 4,800 patients and found that their model, named PLAN-B-CURE, outperformed existing prediction models significantly in various metrics.
- * The results indicate that the PLAN-B-CURE model can be utilized for personalized monitoring of patients post-HBsAg seroclearance, improving long-term health management.
Article Synopsis
- The study focuses on predicting the risk of hepatocellular carcinoma (HCC) in patients with chronic hepatitis B receiving nucleos(t)ide analogues (NAs), emphasizing the importance of serum hepatitis B virus (HBV) RNA as a novel biomarker.
- Researchers analyzed data from 1,374 NA-treated patients, tracking HBV RNA levels over three years and using a Cox proportional-hazard model to assess the link between HBV RNA declines and HCC risk, finding significant associations.
- The findings suggest that patients with lower declines in HBV RNA at one and two years have a higher risk of developing HCC, and incorporating these declines into existing risk prediction models can improve their accuracy and help guide patient monitoring strategies
Background: Statins have multiple benefits in patients with metabolic-associated steatotic liver disease (MASLD).
Aim: To explore the effects of statins on the long-term risk of all-cause mortality, liver-related clinical events (LREs) and liver stiffness progression in patients with MASLD.
Methods: This cohort study collected data on patients with MASLD undergoing at least two vibration-controlled transient elastography examinations at 16 tertiary referral centres.
Background: Hepatocellular carcinoma (HCC) recurrence following surgical resection remains a significant clinical challenge, necessitating reliable predictive models to guide personalised interventions. In this study, we sought to harness the power of artificial intelligence (AI) to develop a robust predictive model for HCC recurrence using comprehensive clinical datasets.
Methods: Leveraging data from 958 patients across multiple centres in Australia and Hong Kong, we employed a multilayer perceptron (MLP) as the optimal classifier for model generation.
Background & Aims: Patients with nonalcoholic fatty liver disease (NAFLD)/metabolic dysfunction-associated steatotic liver disease (MASLD) face a multifaceted disease burden which includes impaired health-related quality of life (HRQL) and potential stigmatization. We aimed to assess the burden of liver disease in patients with NAFLD and the relationship between experience of stigma and HRQL.
Methods: Members of the Global NASH Council created a survey about disease burden in NAFLD.
The effectiveness of magnetic resonance imaging (MRI) iron corrected T1 in monitoring metabolic dysfunction-associated steatohepatitis in obesity following bariatric surgery and lifestyle modification: a prospective cohort study.
Quant Imaging Med Surg
July 2024
Background: Bariatric surgery and lifestyle modification are important treatments for obesity, a risk factor for metabolic dysfunction-associated steatohepatitis (MASH). Studies have related weight reduction with changes in MASH, however, few have used imaging to investigate effects on liver health. We evaluated differences in liver response to obesity treatment using disease activity iron corrected T1 (cT1) and proton density fat fraction (PDFF) in patients with both obesity and metabolic dysfunction-associated steatotic liver disease (MASLD).
View Article and Find Full Text PDFReal-world Effectiveness and Tolerability of Interferon-free Direct-acting Antiviral for 15,849 Patients with Chronic Hepatitis C: A Multinational Cohort Study.
J Clin Transl Hepatol
July 2024
Article Synopsis
- The study aimed to evaluate the effectiveness and tolerability of direct-acting antiviral (DAA) treatments for hepatitis C virus (HCV) across different genotypes (GTs) in a global, real-world context, focusing particularly on GT3 and GT6.
- Researchers analyzed data from 15,849 chronic hepatitis C patients across Asia, North America, and Europe over a seven-year period, noting demographic factors such as age, sex, and prior treatment history.
- Results showed a high sustained virological response (SVR12) rate of 96.9% overall, with variances by genotype, highlighting that independent factors like advanced age, cirrhosis, and previous treatment failures affected treatment outcomes, while being
Metabolic dysfunction-associated steatotic liver disease (MASLD) encompasses a wide spectrum of liver injuries, ranging from hepatic steatosis, metabolic dysfunction-associated steatohepatitis (MASH), fibrosis, cirrhosis to MASLD-associated hepatocellular carcinoma (MASLD-HCC). Recent studies have highlighted the bidirectional impacts between host genetics/epigenetics and the gut microbial community. Host genetics influence the composition of gut microbiome, while the gut microbiota and their derived metabolites can induce host epigenetic modifications to affect the development of MASLD.
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