Publications by authors named "Vincent Portet Sulla"
Background: Commercial immunoassays that detect IgG and IgM directed toward VCA and IgG EBNA are used in combination to assess EBV immune status. However, this strategy does not always confirm/exclude recent/past EBV infection or absence of immunity.
Objectives: The aim of our study was to perform complementary investigations on samples with atypical EBV serological profiles, in order to identify the clinical situation they correspond to.
Background: Early diagnosis of congenital CMV infection (cCMVI) allows for early intervention and follow-up to detect delayed hearing loss. While CMV PCR in urine is the gold standard for cCMVI diagnosis, saliva testing is often performed.
Objectives: Our aim was to determine (i) if swab saliva sampling needed standardization, (ii) if a threshold value in "virus copies per million cells (Mc)" in saliva samples could improve clinical specificity, and (iii) to establish a correlation between viral load in saliva and symptomatology/outcome of cCMVI.
Article Synopsis
- Neonatal herpes simplex virus (HSV) infection is rare but has high mortality and morbidity rates, especially in infants under 6 weeks old, with a retrospective study in France revealing an incidence of 5.5 cases per 100,000 live births over 10 years.
- The predominant serotype found was HSV-1, and many cases were attributed to post-natal transmission through the orolabial route, with early diagnosis and treatment via acyclovir significantly improving outcomes for asymptomatic infants.
- Key risk factors identified for poor outcomes included being born to HSV-seronegative mothers and being preterm, highlighting the need for better understanding and management of HSV infections in neonates.
New Candida species such as Candida auris have emerged recently as important invasive fungal diseases. We report a case of C. bovina bloodstream infection in a 94-year-old patient in France.
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