Publications by authors named "Vincent Kimmel"
Article Synopsis
- Hot melt extrusion using co-rotating twin screw extruders is vital in the pharmaceutical sector, necessitating an in-depth understanding of the process for quality assurance.
- A specialized test rig was constructed to accurately measure key parameters, such as volume flow, pressure, and torque, while advanced 3D simulations employed computational fluid dynamics (CFD) to analyze the performance of different screw designs.
- The results demonstrated a strong correlation between experimental data and the CFD model, indicating enhanced transport capacity and reduced pressure buildup for various screw elements, along with significant efficiency in simulation time compared to traditional methods.
Melt viscosity is an essential property in pharmaceutical processes such as mixing, extrusion, fused deposition modeling, and melt coating. Measuring and modeling of the melt viscosity for drug/polymer mixtures is essential for optimization of the manufacturing process. In this work, the melt viscosity of nine formulations containing the drug substances acetaminophen, itraconazole, and griseofulvin, as well as the pharmaceutical polymers Eudragit EPO, Soluplus, and Plasdone S-630, were analyzed with a rotational and oscillatory rheometer.
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