Intrastriatal injection of α-synuclein can lead to widespread synucleinopathy independent of neuroanatomic connectivity.

Background: Prionoid transmission of α-synuclein (αSyn) aggregates along neuroanatomically connected projections is posited to underlie disease progression in α-synucleinopathies. Here, we specifically wanted to study whether this prionoid progression occurs via direct inter-neuronal transfer and, if so, would intrastriatal injection of αSyn aggregates lead to nigral degeneration.

Methods: To test prionoid transmission of αSyn aggregates along the nigro-striatal pathway, we injected amyloidogenic αSyn aggregates into two different regions of the striatum of adult human wild type αSyn transgenic mice (Line M20) or non-transgenic (NTG) mice and aged for 4 months.

Evaluation, diagnosis, and treatment of shoulder injuries in athletes.

The shoulder remains one of the more challenging joints for clinicians to clearly identify, diagnose, and treat within the athletic population. Its complexities involving the glenohumeral, acromioclavicular, sternoclavicular, and scapulothoracic joints moving in tandem require the physician and rehabilitation specialist to have a comprehensive understanding of the biomechanics and arthrokinematics associated with athletic activity. This chapter focuses on the evaluation, classification, mechanism of injury, and initial treatment of widespread shoulder injuries involved in sports.

Classification of Sport-Related Head Trauma: A Spectrum of Mild to Severe Injury.

OBJECTIVE: To identify the types of injuries the human brain incurs as a result of traumatic forces applied to the cranium. In athletic events and endeavors, the full spectrum of intracranial hemorrhages in various compartments, raised intracranial pressure, and diffuse nonhemorrhagic damage may be seen. In this review, we describe these serious injuries and the more common mild traumatic brain injury in their clinical presentations and relate concussion classification to the overall picture of traumatic brain injury.