Publications by authors named "Vincent Gervat"
Corramycin is a novel zwitterionic antibacterial peptide isolated from a culture of the myxobacterium . Though Corramycin displayed a narrow spectrum and modest MICs against sensitive bacteria, its ADMET and physchem profile as well as its high tolerability in mice along with an outstanding in vivo efficacy in an septicemia mouse model were promising and prompted us to embark on an optimization program aiming at enlarging the spectrum and at increasing the antibacterial activities by modulating membrane permeability. Scanning the peptidic moiety by the Ala-scan strategy followed by key stabilization and introduction of groups such as a primary amine or siderophore allowed us to enlarge the spectrum and increase the overall developability profile.
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- Human relaxin-2 is a hormone important for mediating blood flow changes during pregnancy and has potential benefits in treating acute heart failure, but its clinical use is limited due to a short half-life and requirement for intravenous administration.
- Researchers developed long-acting relaxin peptide mimetics by modifying the B-chain of relaxin, leading to simpler and more potent peptide agonists for the relaxin receptor RXFP1.
- These new lipidated peptide agonists demonstrated high activity, better bioavailability when taken subcutaneously, and longer half-lives, making them promising candidates for wider therapeutic use.