Publications by authors named "Vincent E"

Introduction: Distal femoral cartilage lesions can be treated using osteochondral autograft transfer (OAT). When impacting plugs into a recipient site, the cartilage may fracture. This study aimed to analyze OAT donor regions and impaction energies to identify characteristics that lead to fracture.

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  • * Turtles from the CDF showed signs of higher stress, including elevated glucose levels and altered blood metrics, compared to those from the PCM, which appeared healthier.
  • * Additionally, some turtles tested positive for Chlamydia, with a small number also showing co-infection with herpesvirus, highlighting the need to monitor the impacts of human-altered habitats on wildlife health.
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The Thematic Apperception Test (TAT) is the second most commonly used performance-based task. However, traditional TAT administration is time-consuming and raises accessibility issues. Research exploring administration modifications has found that within a lab setting, having participants type their own narratives leads to richer responses than when participants narrate the stories out loud to an examiner.

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  • The study explores how immune responses can impact drug development for cardiometabolic diseases like type 2 diabetes (T2D) and coronary artery disease (CAD) by examining gene expression during T cell activation.
  • Findings revealed specific genes connected to increased risks of T2D and CAD, with a significant portion showing a particular role tied to CD4 T cells.
  • Additionally, the research identified genes that are potential drug targets currently being investigated, highlighting the importance of immune responses in addressing these diseases.
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  • - The study investigated the potential link between ghrelin, a hormone, and colorectal cancer using a two-sample Mendelian randomization approach, analyzing data from over 54,000 participants.
  • - Results showed no significant association between genetically predicted plasma ghrelin levels and colorectal cancer risk, even when considering factors like sex, cancer subsite, and age at diagnosis.
  • - The findings contribute to the existing evidence suggesting that plasma ghrelin levels do not play a causal role in the development of colorectal cancer.
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Colorectal cancer (CRC) is a multi-stage process initiated through the formation of a benign adenoma, progressing to an invasive carcinoma and finally metastatic spread. Tumour cells must adapt their metabolism to support the energetic and biosynthetic demands associated with disease progression. As such, targeting cancer cell metabolism is a promising therapeutic avenue in CRC.

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  • About 50% of neuroblastomas with poor prognosis are linked to the over-expression of the MYCN protein, and previous research has shown that targeting PRMT5 leads to cell death in these cases.
  • The study evaluates GSK3203591, a new PRMT5 inhibitor, showing that it inhibits MYCN-dependent growth and triggers changes in gene expression and mRNA splicing in MNA neuroblastoma cells, particularly affecting glutamine metabolism.
  • In tests on mice, the related compound GSK3326593 demonstrated increased survival, confirming that both drugs exploit PRMT5's role in splicing and regulation of metabolic pathways in MYCN-amplified neuroblastomas.
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The reactivity of carbamoyl radicals, generated in situ from sodium oxamate salts, has been investigated in the context of radical carbofluorination reactions of olefins and α-fluoroolefins, respectively. Both transformations are catalyzed by silver salts and required the presence of potassium persulfate (KSO) and Selectfluor as a radicophilic fluorine source. The reported methods provide a direct access to β-fluoroamides and β,β-difluoroamides.

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How are romantic relationships across class maintained under broader conditions of class inequality? This article draws on in-depth interviews with 38 people who have partnered across class in Australia. It examines the emotional and interpersonal labour required to preserve such relationships within a highly differentiated class structure that is widely obscured in public and political life. We find, first, that for people in committed cross-class relationships where this difference was openly acknowledged, class difference was acutely felt and described in highly emotional, imprecise terms.

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The evolution of SARS-CoV-2 paired with immune imprinting by prototype messenger RNA (mRNA) vaccine has challenged the current vaccination efficacy against newly emerged Omicron subvariants. In our study, we investigated a cohort of macaques infected by SIV and vaccinated with two doses of bivalent Pfizer mRNA vaccine containing wildtype and BA.5 spikes.

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Superatomic clusters can be assembled to build bulk matter, where the individual characteristics are preserved. The main benefit of these materials over conventional bulk species is the capability to tailor their features by altering the physicochemical identities of individual clusters. Electronic properties of metal clusters can be modified by a protective shell of ligands that attach to the surface and make the whole nanoparticle soluble in organic or aqueous solvents.

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Background: 'Benign ethnic neutropenia' (BEN) is a heritable condition characterized by lower neutrophil counts, predominantly observed in individuals of African ancestry, and the genetic basis of BEN remains a subject of extensive research. In this study, we aimed to dissect the genetic architecture underlying neutrophil count variation through a linear-mixed model genome-wide association study (GWAS) in a population of African ancestry (N = 5976). Malaria caused by P.

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The Masai giraffe () is endangered in the wild, and successful reproduction in managed care is important to help maintain assurance populations of this highly charismatic subspecies. Detection of pregnancy in giraffes using hormonal monitoring requires multiple samples and cannot distinguish pregnancy from pseudopregnancy. A novel enzyme-linked immunosorbent assay that can detect pregnancy-specific protein B (PSPB) for pregnancy diagnosis with a single serum sample was developed from a reticulated giraffe () placenta.

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The pyruvate transporter MPC1 (mitochondrial pyruvate carrier 1) acts as a tumour-suppressor, loss of which correlates with a pro-tumorigenic phenotype and poor survival in several tumour types. In high-grade serous ovarian cancers (HGSOC), patients display copy number loss of MPC1 in around 78% of cases and reduced MPC1 mRNA expression. To explore the metabolic effect of reduced expression, we demonstrate that depleting MPC1 in HGSOC cell lines drives expression of key proline biosynthetic genes; PYCR1, PYCR2 and PYCR3, and biosynthesis of proline.

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Background: Type 2 diabetes is associated with higher risk of several cancer types. However, the biological intermediates driving this relationship are not fully understood. As novel interventions for treating and managing type 2 diabetes become increasingly available, whether they also disrupt the pathways leading to increased cancer risk is currently unknown.

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A 36-yr-old female intact hybrid orangutan ( sp.) presented with evidence of chronic bacterial cystitis with no response to treatment with multiple systemic antibiotics. Abnormalities were identified within the reproductive tract on CT scan, and hysteroscopy was pursued based on the recommendation of an obstetrician-gynecologist.

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Background: Recognizing the early signs of cancer risk is vital for informing prevention, early detection, and survival.

Methods: To investigate whether changes in circulating metabolites characterize the early stages of colorectal cancer (CRC) development, we examined the associations between a genetic risk score (GRS) associated with CRC liability (72 single-nucleotide polymorphisms) and 231 circulating metabolites measured by nuclear magnetic resonance spectroscopy in the Avon Longitudinal Study of Parents and Children (N = 6221). Linear regression models were applied to examine the associations between genetic liability to CRC and circulating metabolites measured in the same individuals at age 8 y, 16 y, 18 y, and 25 y.

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The enteric nervous system (ENS), a collection of neural cells contained in the wall of the gut, is of fundamental importance to gastrointestinal and systemic health. According to the prevailing paradigm, the ENS arises from progenitor cells migrating from the neural crest and remains largely unchanged thereafter. Here, we show that the lineage composition of maturing ENS changes with time, with a decline in the canonical lineage of neural-crest derived neurons and their replacement by a newly identified lineage of mesoderm-derived neurons.

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Objective: To evaluate the outcomes of reinnervation techniques for the treatment of adult unilateral vocal fold paralysis and bilateral vocal fold paralysis.

Methods: A literature review was conducted in the Embase and Medline databases in English, with no limitations on the publication date. The outcome parameters of interest included visual, subjective perceptual, acoustic, aerodynamic analysis and electromyography.

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Deep vein thrombosis (DVT) is the formation of a blood clot in a deep vein. DVT can lead to a venous thromboembolism (VTE), the combined term for DVT and pulmonary embolism, a leading cause of death and disability worldwide. Despite the prevalence and associated morbidity of DVT, the underlying causes are not well understood.

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  • The study investigates the effects of a weight-loss intervention on metabolomic patterns in individuals with type 2 diabetes.
  • The analysis involved 574 serum samples from participants in the Diabetes Remission Clinical Trial and utilized advanced technologies like untargeted mass spectrometry and targeted H-NMR spectroscopy.
  • Key findings reveal that significant reductions in certain metabolites, such as branched-chain amino acids and sugars, were associated with weight loss and diabetes remission, suggesting that these metabolomic patterns can potentially be reversed through effective weight management.
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High body mass index (BMI) is a causal risk factor for endometrial cancer but the tumor molecular mechanisms affected by adiposity and their therapeutic relevance remain poorly understood. Here we characterize the tumor multi-omic landscape of endometrial cancers that have developed on a background of lifelong germline genetic exposure to elevated BMI. We built a polygenic score (PGS) for BMI in women using data on independent, genome-wide significant variants associated with adult BMI in 434,794 women.

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Background: To support proliferation and survival within a challenging microenvironment, cancer cells must reprogramme their metabolism. As such, targeting cancer cell metabolism is a promising therapeutic avenue. However, identifying tractable nodes of metabolic vulnerability in cancer cells is challenging due to their metabolic plasticity.

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Hibernation is a highly seasonal physiological adaptation that allows brown bears (Ursus arctos) to survive extended periods of low food availability. Similarly, daily or circadian rhythms conserve energy by coordinating body processes to optimally match the environmental light/dark cycle. Brown bears express circadian rhythms in vivo and their cells do in vitro throughout the year, suggesting that these rhythms may play important roles during periods of negative energy balance.

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