Publications by authors named "Vincent Dongay"
Drug-tolerance has emerged as one of the major non-genetic adaptive processes driving resistance to targeted therapy (TT) in non-small cell lung cancer (NSCLC). However, the kinetics and sequence of molecular events governing this adaptive response remain poorly understood. Here, we combine real-time monitoring of the cell-cycle dynamics and single-cell RNA sequencing in a broad panel of oncogenic addiction such as EGFR-, ALK-, BRAF- and KRAS-mutant NSCLC, treated with their corresponding TT.
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- Liquid biopsy is gaining traction in cancer research, particularly for non-small cell lung cancer (NSCLC), due to better insights into cancer drivers and resistance to treatments.
- Current blood tests for liquid biopsy have limited sensitivity, especially when tumor volumes are low, leading to the need for confirmatory biopsies that can yield small, less useful samples for genetic testing.
- Other body fluids besides blood, such as urine and cerebrospinal fluid, may offer richer sources of tumor DNA, enabling more effective applications of circulating tumor DNA analysis in NSCLC from early detection to metastasis.