Publications by Vincent Darmohusodo

Publications by authors named "Vincent Darmohusodo"

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Discovery and Development of S6821 and S7958 as Potent TAS2R8 Antagonists.

Joseph R Fotsing Vincent Darmohusodo Andrew P Patron Brett W Ching Thomas Brady

J Med Chem

May 2020

In humans, bitter taste is mediated by 25 TAS2Rs. Many compounds, including certain active pharmaceutical ingredients, excipients, and nutraceuticals, impart their bitter taste (or in part) through TAS2R8 activation. However, effective TAS2R8 blockers that can either suppress or reduce the bitterness of these compounds have not been described.

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Vincent Darmohusodo's research primarily focuses on developing antagonists for bitter taste receptors, specifically TAS2R8, to address the challenge of bitterness in pharmaceutical compounds.
His 2020 article, "Discovery and Development of S6821 and S7958 as Potent TAS2R8 Antagonists," highlights the lack of effective TAS2R8 blockers in the pharmaceutical industry.
The study presents the novel compounds S6821 and S7958 as potential solutions to mitigate bitterness, which could enhance patient compliance and acceptance of bitter-tasting medications.

Publications by authors named "Vincent Darmohusodo"

Discovery and Development of S6821 and S7958 as Potent TAS2R8 Antagonists.

Synopsis of recent research by authors named "Vincent Darmohusodo"