Publications by authors named "Vincent Azzolino"
Article Synopsis
- Enterovirus-D68 (EV68) is a growing global health threat, causing severe infections that can lead to long-term neurological issues and fatalities, with no FDA-approved antiviral treatments currently available.
- Researchers are investigating small molecule inhibitors that target the EV68-3C protease's active site, aiming to reduce the risk of drug resistance by understanding substrate specificity.
- The study utilized molecular modeling and co-crystal structures to determine the substrate specificity of EV68-3C protease, revealing how it interacts with viral peptides and calculating a substrate envelope to better understand how existing inhibitors might work and predict possible resistance mutations.
How patient and tumor factors influence clearance margins and the number of Mohs Micrographic Surgery (MMS) stages when treating basal cell carcinoma (BCC) remains widely uncharacterized. It is important to elucidate these relationships, as surgical outcomes may be compared nationally between colleagues. Our objective is to evaluate the relationships between defect size and patient demographics, as well as between BCC subtypes and the number of MMS stages.
View Article and Find Full Text PDFVitiligo is an autoimmune disease of the skin mediated by CD8 T cells that kill melanocytes and create white spots. Skin lesions in vitiligo frequently return after discontinuing conventional treatments, supporting the hypothesis that autoimmune memory is formed at these locations. We found that lesional T cells in mice and humans with vitiligo display a resident memory (T) phenotype, similar to those that provide rapid, localized protection against reinfection from skin and mucosal-tropic viruses.
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