Publications by authors named "Vincent Appiah"
Malaria causes significant morbidity and mortality worldwide, disproportionately impacting sub-Saharan Africa. Disease phenotypes associated with infection can vary widely, from asymptomatic to life-threatening. To date, prevention efforts, particularly those related to vaccine development, have been hindered by an incomplete understanding of which factors impact host immune responses resulting in these divergent outcomes.
View Article and Find Full Text PDFThe COVID-19 pandemic is one of the fastest evolving pandemics in recent history. As such, the SARS-CoV-2 viral evolution needs to be continuously tracked. This study sequenced 1123 SARS-CoV-2 genomes from patient isolates (121 from arriving travellers and 1002 from communities) to track the molecular evolution and spatio-temporal dynamics of the SARS-CoV-2 variants in Ghana.
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- - Governments worldwide adopted varying strategies to combat COVID-19, with some aiming for herd immunity despite the WHO deeming it unethical, leading to increased viral diversity and potential health risks.
- - A study utilizing the CovidSim model investigated the impact of multi-infections on COVID-19 morbidity and mortality in the U.S., simulating scenarios of contact reductions and the spread of infections.
- - Results showed that while multi-infections could lead to fewer overall infections due to higher isolation rates, they significantly increased mortality, highlighting the effectiveness of a potential second lockdown in reducing infections and deaths.
Background: Malaria is still a major global health burden, with more than 3.2 billion people in 91 countries remaining at risk of the disease. Accurately distinguishing malaria from other diseases, especially uncomplicated malaria (UM) from non-malarial infections (nMI), remains a challenge.
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