Relationship between visual field severity and response to fixed combination dorzolamide/timolol or timolol alone.

Purpose: To examine the response to intraocular pressure (IOP)-lowering medications as a function of glaucoma severity represented by visual field defects.

Methods: Post hoc analysis of a multicenter, double-masked, parallel study comparing the 24-h efficacy of the dorzolamide/timolol fixed combination (N = 117) versus timolol alone (N = 115) in patients with open-angle glaucoma or ocular hypertension. Visual field scoring was performed independently by three glaucoma specialists.

24-hour control of intraocular pressure with 2% dorzolamide/0.5% timolol fixed-combination ophthalmic solution in open-angle glaucoma.

Objective: To evaluate the 24-hour efficacy and tolerability of 2% dorzolamide/0.5% timolol fixed combination (DTFC) solution in open-angle glaucoma and ocular hypertension.

Research Design And Methods: Randomized, parallel, double-masked, multicenter study.