Publications by authors named "Vince W H Lau"
Article Synopsis
- The study compares the effectiveness and safety of combining stereotactic body radiotherapy (SBRT) with immunotherapy versus SBRT alone in patients with unresectable hepatocellular carcinoma.
- Results show that the combination therapy (SBRT-IO) led to significantly improved overall survival rates and response compared to SBRT alone, with higher rates of complete and partial responses among patients.
- Despite some cases of severe side effects from immunotherapy, the combination treatment demonstrated better outcomes, suggesting that further research through randomized trials is needed.
Deep Learning Algorithm of the SPARCC Scoring System in SI Joint MRI.
J Magn Reson Imaging
October 2024
Background: The Spondyloarthritis Research Consortium of Canada (SPARCC) scoring system is a sacroiliitis grading system.
Purpose: To develop a deep learning-based pipeline for grading sacroiliitis using the SPARCC scoring system.
Study Type: Prospective.
Sequential transarterial chemoembolisation and stereotactic body radiotherapy followed by immunotherapy as conversion therapy for patients with locally advanced, unresectable hepatocellular carcinoma (START-FIT): a single-arm, phase 2 trial.
Lancet Gastroenterol Hepatol
February 2023
Background: The synergy between locoregional therapies and immune checkpoint inhibitors has not been investigated as conversion therapy for unresectable hepatocellular carcinoma. We aimed to investigate the activity of sequential transarterial chemoembolisation (TACE) and stereotactic body radiotherapy followed by avelumab (an anti-PD-L1 drug) for locally advanced, unresectable hepatocellular carcinoma.
Methods: START-FIT was a single-arm, phase 2 trial in patients with locally advanced hepatocellular carcinoma who were not suitable for curative treatment, conducted in two hospitals in Hong Kong and one in Shenzhen, China.
Article Synopsis
- A study evaluated the relationship between MRI-derived apparent diffusion coefficient (ADC) measurements of spinal lesions and disease activity in patients with axial spondyloarthritis (SpA).
- 243 participants, meeting specific criteria for SpA, underwent whole-spine MRI to identify discovertebral lesions and assess various clinical parameters.
- Findings indicated that higher ADC values were significantly linked to increased levels of disease activity, as measured by functional and pain-related indices, suggesting ADC could be a useful indicator of inflammation intensity in SpA.
Objectives: To investigate the usefulness of diffusion weighted imaging (DWI) by comparing with clinical features, blood parameters and traditional short tau inversion recovery (STIR) sequence in detecting spinal and sacroiliac (SI) joint inflammation in axial spondyloarthritis (axSpA) patients.
Methods: One hundred and ten axSpA patients were recruited. Clinical, radiological and blood parameters were recorded.
Kimura's disease is a rare chronic inflammatory disorder predominantly affecting young Asian male patients, occurring mainly in the head and neck regions. Kimura's disease of the upper extremity is extremely rare, and previous case reports in the literature show similar imaging characteristics with consistent location at the medial epitrochlear region, predominantly with unilateral involvement. We present the first reported case of Kimura's disease affecting the anterolateral aspect of the upper arm, sparing the medial epitrochlear region, illustrating that with typical MR appearance and serology, the involvement of this rare disease in an atypical location still warrants consideration of this diagnosis.
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