Publications by authors named "Vince J Sullivan"
Packaging of drugs in prefillable syringes offers considerable advantages over conventional vials. Almost all major biotech molecules are available on the market today in prefilled syringes, and are safe and efficacious. Newer high-concentration liquid formulations, especially fusion proteins, however, can suffer from instability in prefilled syringes due to syringe components like silicone oil.
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- The recombinant plague antigen F1-V exhibits a larger molecular weight than expected due to its disordered, worm-like conformation, indicated by various biophysical analyses.
- Its solubility profile shows a minimum at pH 5, suggesting a tendency to aggregate when it lacks repulsive forces near its isoelectric point (pI).
- When gradually renatured with specific conditions, F1-V stabilizes mainly in its monomeric form despite its innate propensity for aggregation as an unfolded protein.