Design, Synthesis and Evaluation of Antifungal Activity of Pyrazoleacetamide Derivatives.

Background: Fungal infections have posed a big challenge in the management of their treatment. Due to the resistance and toxicity of existing drug molecules in the light of pandemic infections, like COVID-19, there is an urgent need to find newer derivatives of active molecules, which can be effective in fungal infections.

Objective: In the present study, we aimed to design pyrazole derivatives using molecular modeling studies against target 1EA1 and synthesize 10 molecules of pyrazole derivatives using a multi-step synthesis approach.

Enhanced supercapacitor performance of a Cu-FeO/g-CN composite material: synthesis, characterization, and electrochemical analysis.

A Cu-doped FeO/g-CN composite, synthesized a straightforward hydrothermal process with controlled morphologies, represents a significant advancement in supercapacitor electrode materials. This study systematically analyzes the impact of Cu doping in FeO and its synergistic combination with g-CN to understand their influence on the electrochemical performance of the resulting composite, focusing on Cu doping in FeO rather than varying FeO/g-CN content. The comprehensive characterization of these composites involved a suite of physicochemical techniques.

gene promoter methylation and its correlation with clinicopathological parameters in glioblastomas.

Background: MGMT (O-methyl guanine DNA methyl transferase) promoter hypermethylation is a prognostic and predictive biomarker for glioblastomas (GBM).

Aims: To evaluate the frequency of MGMT methylation status in a single institute series of 134 GBMs and correlate it with clinical (age, sex, location, survival) and other molecular parameters [such as p53 expression, alpha thalassemia/mental retardation syndrome X-linked (ATRX) expression, isocitrate dehydrogenase (IDH) 1R132H mutation, and epidermal growth factor receptor (EGFR) gene amplification].

Results: One hundred and thirty-four GBMs were evaluated by methylation-specific polymerase chain reaction (MSP) for MGMT promoter methylation status.

Development of colon targeted multiparticulate pulsatile drug delivery system for treating nocturnal asthma.

The aim of the present study was to develop theophylline fast release enteric-coated pellets as a pulsatile drug delivery to the colon. The novelty of this work is the combination of pH and time-dependant enteric polymers as a single coating for the development of multiparticulate formulation. Theophylline pellets were optimized by applying a 2-factors 3-levels full factorial design.

Formulation and evaluation of press coated tablets for pulsatile drug delivery using hydrophilic and hydrophobic polymers.

The aim of present investigation was to develop press coated tablet for pulsatile drug delivery of ketoprofen using hydrophilic and hydrophobic polymers. The drug delivery system was designed to deliver the drug at such a time when it could be most needful to patient of rheumatoid arthritis. The press coated tablets containing ketoprofen in the inner core was formulated with an outer shell by different weight ratio of hydrophobic polymer (micronized ethyl cellulose powder) and hydrophilic polymers (glycinemax husk or sodium alginate).

Formulation and evaluation of a pulsatile drug delivery system using time- and pH-dependant polymers.

The aim of the present study was to develop fast-release enteric-coated tablets for pulsatile drug delivery to the colon. The novelty of this work is a combination of pH- and time-dependant enteric polymers as a single coating. Eudragit S100 was used as a pH-dependant polymer and eudragit RL100 was used as a time-dependant polymer.