Publications by authors named "Vinaya C Maddukuri"
Article Synopsis
- The study analyzed 108 subjects with acute porphyrias, focusing on their clinical, biochemical, and genetic features, highlighting a significant prevalence among women and common late diagnosis.
- The most prevalent symptom was abdominal pain, with many patients undergoing unnecessary surgeries like appendectomies before receiving a proper diagnosis, which took an average of 15 years.
- Genetic testing revealed new mutations in many patients, and intravenous hematin emerged as the most effective treatment for both acute episodes and prevention of future attacks.*
Acute liver failure (ALF) during pregnancy is very uncommon. Pregnancy-specific liver conditions like hemolysis, elevated liver enzymes, and low platelets (HELLP) syndrome and acute fatty liver of pregnancy can cause ALF at term or postpartum, but, typically occur during the third trimester. Most of these patients recover spontaneously after delivery, but, on occasion, they require liver transplantation in the postpartum period.
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