A novel ITGB8 transcript variant sustains ovarian cancer cell survival through genomic instability and altered ploidy on a mutant p53 background.

Background: Transcript variants and protein isoforms are central to unique tissue functions and maintenance of homeostasis, in addition to being associated with aberrant states such as cancer, where their crosstalk with the mutated tumor suppressor p53 may contribute to genomic instability and chromosomal rearrangements. We previously identified several novel splice variants in ovarian cancer RNA-sequencing datasets; herein, we aimed to elucidate the biological effects of the Integrin Subunit Beta 8 variant (termed pITGB8-205).

Methods: Resolution of the full-length sequence of pITGB8-205 through rapid amplification of cDNA ends (RACE-PCR).

Incidence of Carotid Wall Irregularities in Acute Ischemic Stroke Patients: A Descriptive Analysis.

Background Carotid wall abnormalities are significant predictors of cardiovascular events, including ischemic stroke. Identifying the clinical and biochemical risk factors associated with these abnormalities can aid in early intervention and prevention strategies. This study aimed to assess the association between lipid profiles, age, gender, smoking habits, hypertension, and carotid wall abnormalities in patients.

Creating Novel Standards for Datapoints on an Elective Orthopaedic Theatre List Document.

Introduction: Orthopaedic theatre lists are an important tool which must convey essential information to all staff to run an effective and safe theatre list. However, there are no set standards or guidelines on the components of an Orthopaedic theatre list. The objective of this study is to formulate guidelines for elective Orthopaedic theatre lists which improve efficiency and reduce errors.

Unsupervised classification of brain-wide axons reveals the presubiculum neuronal projection blueprint.

We present a quantitative strategy to identify all projection neuron types from a given region with statistically different patterns of anatomical targeting. We first validate the technique with mouse primary motor cortex layer 6 data, yielding two clusters consistent with cortico-thalamic and intra-telencephalic neurons. We next analyze the presubiculum, a less-explored region, identifying five classes of projecting neurons with unique patterns of divergence, convergence, and specificity.

Unsupervised classification of brain-wide axons reveals neuronal projection blueprint.

Long-range axonal projections are quintessential determinants of network connectivity, linking cellular organization and circuit architecture. Here we introduce a quantitative strategy to identify, from a given source region, all "projection neuron types" with statistically different patterns of anatomical targeting. We first validate the proposed technique with well-characterized data from layer 6 of the mouse primary motor cortex.

Substance use and oral health sensations among substance users residing in rehabilitation centres in an Indian City.

Background: The term substance is usually used to address psychoactive/psychotropic drugs which include both licit and illicit drugs. These substances have varied consequences, including long-term and short-term effects, which include sensations post-consumption.

Aim: To determine patterns of substance use and short-term oral health effects among substance users.

An insight into the world of sports dentistry.

Dental trauma in the field of sports is the major linking channel between sports and dentistry. Sports dentistry is the branch of sports medicine that deals with the prevention of oral or facial athletic injuries, oral diseases and manifestations. Sports dentistry is also related to mild traumatic brain injuries during games and erosive lesions due to continuous intake of highly acidic sports and energy drinks.

A validated audio-visual educational module on examination skills in ophthalmology for undergraduate medical students in the COVID-19 season - An observational longitudinal study.

Purpose: The aim of this study was to assess the impact of an audio visual (AV) teaching module on basic torchlight examination of the eye and direct ophthalmoscopy for undergraduate medical students.

Methods: This observational longitudinal study was done on 33 consecutive medical interns during their Ophthalmology posting from December 2019 to March 2020 at a medical college in South-India. An AV-module was created using animation graphics, narratives, demonstrations on normal individuals and on patients with positive signs.

Knowledge, attitude, practices, and barriers regarding pharmacovigilance and adverse drug reaction reporting among medical and dental faculties of the teaching hospitals in Bhubaneswar City.

Aim: To assess the knowledge, attitude, practices (KAP), and barriers regarding pharmacovigilance and adverse drug reaction (ADR) reporting among medical and dental faculties of the teaching hospitals.

Methodology: This study was conducted for a period of 3 months among medical and dental faculties. A self-structured, 42-item closed-ended questionnaire based on pharmacovigilance and ADR reporting was used in this study.

Management of chronic scapholunate ligament injury.

Scapholunate ligament is the most commonly injured ligament in the wrist and requires accurate diagnosis and treatment. It presents with pain, stiffness and can lead to carpal instability as well as degenerative arthritis if left untreated, with subsequent loss of function and disability. There are several management options currently available but there is no consensus on how best to manage a wrist with chronic sequelae of scapholunate ligament injury.

Geo-visualization of landscape dynamics in the proposed mega industrial corridor.

Urbanization is associated with large-scale irreversible landscape changes in response to the demands of burgeoning population, etc. Lack of basic amenities, job, and infrastructures in rural areas often drives migration towards the urbanizing landscapes. Urbanization is resource centric, which involves, large-scale transformation of the landscape with the irreversible impacts on the regional ecology, hydrology, and environment, which is evident from large-scale land cover changes leading to deforestation, encroachment of lakes/water bodies, forest, and farmlands, conversion of agriculture landscapes, etc.

DNA damage and gene expression changes in patients exposed to low-dose X-radiation during neuro-interventional radiology procedures.

Interventional radiology-based imaging is the preferred choice for diagnosis and therapy of many complex diseases, despite possible adverse effects of the radiation exposures. We have measured induced DNA damage and changes in gene expression in relation to entrance surface dose (ESD) in peripheral blood samples of patients (n = 51) who underwent neuro-interventional radiological procedures. The ESD values, measured by thermoluminescence dosimetry, were 4.

Eco-Hydrological Footprint of a River Basin in Western Ghats.

Eco-Hydrological footprint of a river basin refers to the hydrologic regime for sustaining vital ecological functions considering the appropriation of water by biotic components (including humans). It provides crucial information about the ecological status of a river, while addressing the divergence from natural conditions of the actual hydrological regime. Thus, this highlights the implicit relationship of hydrologic regime in meeting the demand of the biota.

"Is Cone Beam Computed Tomography (CBCT) a Potential Imaging Tool in ENT Practice?: A Cross-Sectional Survey Among ENT Surgeons in the State of Odisha, India.

This questioner survey aimed about awareness of the Cone Beam Computed Tomography (CBCT) machine and its various clinical applications in ENT, among the ENT surgeons in the state of Odisha. 150 questioner forms on CBCT were distributed to the all the participating ENT surgeons at a state level ENT conference, out of which the response rate was 110. The participants were asked to answer 30 multiple choice questions, which were divided into 3 parts; general information on CBCT, general approach to CBCT and practice related to CBCT.

Surgical outcomes and complications of sutured scleral fixated intraocular lenses in pediatric eyes.

Objective: To study the outcome and complications of sutured scleral fixated intraocular lenses (SSFIOL) in children.

Design: Retrospective study.

Subjects: A total of 279 eyes of 230 children who underwent SSFIOL at ≤18 years of age in a tertiary eye care centre in India.

Spatial patterns of heavy metal accumulation in sediments and macrophytes of Bellandur wetland, Bangalore.

Heavy metals are one among the toxic chemicals and accumulation in sediments and plants has been posing serious health impacts. Wetlands aid as kidneys of the landscape and help in remediation through uptake of nutrients, heavy metals and other contaminants. The analyses of macrophytes and sediment samples help in evaluating pollution status in aquatic environment.

Quantification of annual sediment deposits for sustainable sand management in Aghanashini river estuary.

Sedimentation involving the process of silt transport also carries nutrients from upstream to downstream of a river/stream. Sand being one of the important fraction of these sediments is extracted in order to cater infrastructural/housing needs in the region. This communication is based on field research in the Aghanshini river basin, west coast of India.

Green to gray: Silicon Valley of India.

Rapid growth, population concentration and the expansion of urban areas towards peri-urban regions have led to changes in urban structure and composition, and consequently changes in urban ecology. The purpose of this study is to estimate trees in the urban environment through quantification of vegetation cover using multi resolution spatial data supplemented with tree data acquired from field using pre-calibrated GPS. Optimal resolution for extracting trees was attained through fusion of multi resolution (spectral and spatial) data.

The Unexplored Anticaries Potential of Shiitake Mushroom.

Keeping an eye the escalating costs of dental services, the treatment cost of the consequences of dental caries can be reduced to manageable proportions by preventive measures aimed at decreasing the prevalence. One such measure is by increasing the consumption of caries preventive foods. Recently, there has been an upsurge of interest in mushrooms not only as a healthy food but also as a caries preventive food.

How atypical can Atypical Hemolytic Uremic Syndrome be?

A 24-year-old man with diarrhea found to have acute renal failure with microangiopathic hemolytic anemia (MAHA). A diagnosis of hemolytic uraemic syndrome (HUS) was made. He was initiated on plasma exchange and hemodialysis.

Knowledge, attitude and practices of denture adhesives use among private dental practitioners' of jabalpur city, madhya pradesh: a cross sectional survey.

The use of denture adhesives (DA) and their role in prosthodontics has been a conflicted topic both in clinical practice and dental education. The use of adhesives, are viewed as poor reflection of their clinical skills and prosthetic expertise or to provide retention to an ill-fitting prosthesis by many dentists. These conflicting views have raised many doubts among practicising dentists on the use of DAs in their clinical practice.

Dental prosthetic status and prosthetic needs of institutionalised elderly population in oldage homes of jabalpur city, madhya pradesh, India.

Oral disorders are cumulative throughout life and hence unfavourable outcomes are likely to be greatest among the elderly. A descriptive cross-sectional study was conducted among institutionalized geriatric population in old-age homes of Jabalpur city, Madhya Pradesh, to assess their prosthetic status and prosthetic needs. A cross-sectional survey was conducted in all the four old-age homes of Jabalpur city, Madhya Pradesh state, India.