Publications by authors named "Vinay K Mishra"

The cultivation of nearly 10,000 indigenous rice landraces in the North-Eastern Hill (NEH) region by various ethnic groups creates opportunities for the utilization of unique landraces through systematic evaluation of genetic variability. In the present study, a set of 102 rice landraces were assessed based on morphological and SSR markers, and five checks in augmented design vis-à-vis high-yielding rice genotypes with stable performance were identified. The presence of high estimates of heritability, genotypic coefficient of variation, and genetic advance over mean indicated the predominance of additive gene action, which necessitated the effectiveness of selection in augmenting productivity.

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  • - Conventional breeding has improved crop yields since the mid-1900s, but genomics introduces advanced tools for studying whole genomes, enhancing the accuracy of crop development.
  • - Techniques like molecular markers, genomic selection, and genome editing (e.g., CRISPR/Cas9) allow for precise trait mapping and faster breeding, improving characteristics like yield, resistance to disease, and stress tolerance.
  • - The paper discusses how genomic resources aid in plant breeding by identifying important traits, understanding genetic diversity, and speeding up breeding programs, ultimately leading to the creation of new plant varieties.
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The present experiment was carried out to investigate the role of Oxyrase in preserving the in vitro quality, redox status and in vivo fertility of crossbred boar spermatozoa. A total of 24 ejaculates from 6 crossbred (n = 4 from each boar) boars were collected and extended in Beltsville Thawing Solution (BTS) in 1:2 ratio and divided into three aliquots. The first aliquot served as a control (without Oxyrase).

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  • There is an increasing need to incorporate underutilized crops like perilla seeds into mainstream agriculture to improve nutrition and sustainability in food systems.
  • Perilla seeds are nutrient-dense, high in ω-3 fatty acids and other beneficial compounds, which provide various health benefits such as antioxidant and anti-inflammatory effects.
  • The review discusses advances in genetic research for crop improvement and explores the applications of perilla seeds in functional foods and the food industry, aiming to promote sustainable agricultural practices and product innovation.
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Northeastern states of India are known for unique landraces of spp. with geographical indications. However, little information is available about these valuable landraces of chillies.

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A new strategy for synthesizing chirally enriched pyrazolylpyrimidinone-based glycohybrids has been achieved, employing an annulation approach in ethanol without any additives or catalysts under microwave conditions. The designed compounds were obtained within a short reaction time (5 min). This method offers several advantages, including mild reaction conditions, a green solvent, and a metal-free approach.

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  • * Combining carbohydrate molecules with bioactive frameworks leads to diverse compound libraries that are crucial for developing effective drugs with various functional benefits.
  • * A comprehensive review from 2015 to 2023 highlights synthesized glycohybrids showing strong bioactivity in areas like anti-microbial and anti-cancer properties, suggesting their potential as innovative drug development tools.
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Hybrid molecules maintain their stronghold in the drug market, with over 60% of drug candidates in pharmaceutical industries. The substantial expenses for developing and producing biologically privileged drugs are expected to create opportunities for producing hybrid molecule-based drugs. Therefore, we have developed a simple and efficient copper-catalyzed approach for synthesizing a wide range of triazole-linked glycohybrids derived from pyrazolo[1,5-a]pyrimidines.

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In the pursuit of novel therapeutic agents, we present a comprehensive study on the design, synthesis, and evaluation of a diverse library of triazole bridged -glycosides of pyrazolo[1,5-]pyrimidinones, employing a microwave-assisted synthetic approach 'click chemistry'. This methodology offers efficient and accelerated access to the glycohybrids, showcasing improved reaction conditions that yield high-quality products. In this research endeavor, we have successfully synthesized a series of twenty-seven triazole bridged -glycosides of pyrazolo[1,5-]pyrimidinones.

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  • Microwave energy has become increasingly popular in chemistry, enabling innovative applications in medicinal chemistry, materials science, and organic synthesis.
  • This literature review focuses on how microwave-assisted organic synthesis can efficiently produce a variety of heterocycles with high yield and selectivity, particularly N- and O-containing compounds known for their bioactive properties.
  • Specific heterocycles like pyrazolopyrimidines, coumarins, quinolines, and isatins are emphasized for their potential in drug discovery, showcasing recent trends and protocols in synthesizing these important molecules.
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  • - Viral infections are a major health issue globally, leading to more complications and deaths, highlighting the need for effective treatment options for emerging viruses.
  • - There is a growing challenge in treating various viruses, like HIV and SARS-CoV-2, due to resistance to existing medications, necessitating the discovery of new antiviral small molecules with different mechanisms.
  • - The review focuses on advancements in antiviral drug development based on natural products, discussing FDA-approved drugs, molecular docking studies, and the discovery of new inhibitors for viruses like HIV and SARS-CoV.
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Reclamation of alkali soils to harness their productivity potential is more complex due to the presence of excess sodium ions, poor hydraulic conductivity and infiltration rate, resulting in poor plant growth and crop productivity. Sodic soil reclamation using inorganic ameliorants like mineral gypsum or phosphogypsum is beyond the reach of small and marginal farmers having alkali soils because of their higher market prices and shortage of availability. Conjoint use of inorganic and organic amendments can be a pragmatic solution for improving soil physico-chemical and biological properties and sustaining crop productivity.

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Introduction: Millets are nutritionally superior and climate-resilient short-duration crops and hold a prominent place in cropping sequences around the world. They have immense potential to grow in a marginal environment due to diverse adaptive mechanisms.

Methods: An experiment was conducted in an organic production system in the North Eastern Himalayan foothills of India for 3 consecutive years by evaluating high-yielding varieties (HYVs) of different millets, viz.

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The first electrochemical molecular iodine promoted, domino reactions for the green synthesis of biologically relevant dicyano 2-(2-oxoindolin-3-ylidene) malononitriles (11 examples, up to 94% yield) from readily available isatin derivatives, malononitrile, and iodine at room temperature have been presented. This synthesis method showed tolerance towards various EDG and EWG and was completed in a short reaction time at the constant low current density of 5 mA cm in the low redox potential range of -0.14 to 0.

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  • - Aroids, significant indigenous tuber crops, were studied in northeastern India, revealing 53 genotypes with diverse growth and quality traits, including varying plant heights and sugar content.
  • - A total of 16 landraces were documented, with landrace Rengama being the most dominant in shifting farming systems, while Pugarkusu and Chigi thrived in backyard farming.
  • - The research highlighted high genetic diversity among the Aroids, with certain landraces like Tamachongkham and Tasakrek having unique culinary uses due to their nutritional profiles, and genetic analysis showing substantial variability among genotypes.
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The eastern Himalayas, one of the important hotspots of global biodiversity, have a rich diversity of wild edible fruit trees. The fruits of these tree species have been consumed by the tribal people since time immemorial. However, there is limited information available on the biochemical and antioxidant properties of the fruits.

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  • * The study explored how using crop residue in conservation tillage improves zinc uptake in rice and wheat grown in reclaimed sodic soil.
  • * Results showed that planting techniques that retain crop residue significantly enhance zinc intake, suggesting strategies for better nutritional security and reduced environmental harm from crop burning.
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The reactive oxygen species (ROS) which are produced during storage of boar semen are causing oxidative stress and leads to poor fertility. Also, tropical and sub-tropical weather condition adversely impacts the physicomorphological quality and fertility of boar sperm. The aim of this study was to examine the effects of feeding linseed oil to boar on its seminal attributes, sperm kinetics, biomarkers of antioxidant, fatty acid profile of seminal plasma (SP) and sperm and in vivo fertility.

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wilt in bananas is one of the most devastating diseases that poses a serious threat to the banana industry globally. With no effective control measures available to date, biological control has been explored to restrict the spread and manage the outbreak. We studied the effective biological control potential of different spp.

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Cardenolide and pregnatriene compounds were isolated from the chloroform fraction of the 95% aqueous ethanolic extract of dried roots of . The stereochemical structure of the cardenolide and pregnatriene compounds was determined to be 3β--(D-diginosyl)-14β-hydroxy card-20(22)-enolide and 12β-hydroxy pregna-4,6,16-triene-3,20-dione using spectroscopic methods including IR, HRMS and NMR spectroscopy.

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In this study, 285 lentil genotypes were phenotyped under hydroponic and alkaline field conditions. Significant genotypic variation for alkalinity stress was observed among the six Lens species screened hydroponically and in the field having pH up to 9.1.

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Aims: The purpose of this study was to compare the effect of enamel wetness on microshear bond strength using different adhesive systems.

Objectives: To evaluate microshear bond strength of three bonding agents on dry enamel; to evaluate microshear bond strength of three bonding agents on wet enamel; and to compare microshear bond strength of three different bonding agents on dry and wet enamel.

Materials And Methods: Sixty extracted noncarious human premolars were selected for this study.

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The presence of environmental fluoride and its impact on human health is well documented. When consumed in adequate quantity, fluoride prevents dental caries, assists in the formation of dental enamels, and prevents deficiencies in bone mineralization. At excessive exposure levels, ingestion of fluoride causes dental fluorosis skeletal fluorosis, and manifestations such as gastrointestinal, neurological, and urinary problems.

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