Coarse grained MD simulation of bulk and interfacial behavior of mixture of CTAB/SDS surfactants.

Context: This study involves simulating the process of inhibiting corrosion through the formation of micelles by surfactants and their deposition on iron (Fe) surfaces. The primary focus is on examining CTAB/SDS mixtures in aqueous solutions with different concentrations. Micelle properties, including size, shape, aggregation number, cluster size, and surfactant diffusion, were calculated and validated with experimental data.

Design, optimization, and evaluation of topical gel of and leaves extract for the treatment of rheumatoid arthritis.

This research aims to develop and assess the anti-arthritic properties of a topically herbal gel including leaf extracts from and . in rats. Utilizing gelling agents carbopol 940 (2.

Blockchain technology: A potential tool for the management of pharma supply chain.

Background: The pharma supply chain comprises various parties including distributors, manufacturers, raw material suppliers, regulators, pharmacies, hospitals, and patients. Due to the product's complexity and transaction flows, an efficient traceability system is needed in the pharma supply chain to identify the current and all previous product owners. Digitizing the track and trace process significantly improves regulatory oversight and guarantees product quality.

Stem cells in regenerative dentistry: Current understanding and future directions.

Background: Regenerative dentistry aims to enhance the structure and function of oral tissues and organs. Modern tissue engineering harnesses cell and gene-based therapies to advance traditional treatment approaches. Studies have demonstrated the potential of mesenchymal stem cells (MSCs) in regenerative dentistry, with some progressing to clinical trials.

Crenolanib and Intensive Chemotherapy in Adults With Newly Diagnosed FLT3-Mutated AML.

Purpose: Crenolanib is a second-generation tyrosine kinase inhibitor with activity against - and -mutant AML. We conducted a trial of crenolanib plus intensive chemotherapy in adults with newly diagnosed -mutant AML.

Methods: Eligible patients were 18 years and older.

Non-linear dose response of DNA double strand breaks in response to chronic low dose radiation in individuals from high level natural radiation areas of Kerala coast.

Background: The human population living in high level natural radiation areas (HLNRAs) of Kerala coast provide unique opportunities to study the biological effects of low dose and low dose rate ionizing radiation below 100 mGy. The level of radiation in this area varies from < 1.0 to 45 mGy/year.

Determination of bioavailable arsenic threshold and validation of modeled permissible total arsenic in paddy soil using machine learning.

Minimizing arsenic intake from food consumption is a key aspect of the public health response in arsenic (As)-contaminated regions. In many of these regions, rice is the predominant staple food. Here, we present a validated maximum allowable concentration of total As in paddy soil and provide the first derivation of a maximum allowable soil concentration for bioavailable As.

Addressing the genetic/nongenetic duality in cancer with systems biology.

The dogma that cancer is a genetic disease is being questioned. Recent findings suggest that genetic/nongenetic duality is necessary for cancer progression. A think tank organized by the Shraman Foundation's Institute for Theoretical Biology compiled key challenges and opportunities that theoreticians, experimentalists, and clinicians can explore from a systems biology perspective to provide a better understanding of the disease as well as help discover new treatment options and therapeutic strategies.

A Deep Ranking Weighted Multihashing Recommender System for Item Recommendation.

Collaborative filtering (CF) techniques are used in recommender systems to provide users with specialised recommendations on social websites and in e-commerce. But they suffer from sparsity and cold start problems (CSP) and fail to interpret why they recommend a new item. A novel deep ranking weighted multihash recommender (DRWMR) system is designed to suppress sparsity and CSP.

Evaluation of natural chronic low dose radiation exposure on telomere length and transcriptional response of shelterin complex in individuals residing in Kerala coast, India.

The high level natural radiation areas (HLNRA) of Kerala coast provide unique opportunity to study the biological effect of chronic low dose ionizing radiation (LDIR) on human population below 100 mSv. The radiation level in this area varies from < 1.0-45 mGy /year due to patchy distribution of monazite in the sand, which contains Th (8-10%), U (0.

Phase I study using crenolanib to target PDGFR kinase in children and young adults with newly diagnosed DIPG or recurrent high-grade glioma, including DIPG.

Background: Platelet-derived growth factor receptor (PDGFR) signaling has been directly implicated in pediatric high-grade gliomagenesis. This study evaluated the safety and tolerability of crenolanib, a potent, selective inhibitor of PDGFR-mediated phosphorylation, in pediatric patients with high-grade glioma (HGG).

Methods: We used a rolling-6 design to study the maximum tolerated dose (MTD) of once-daily crenolanib administered during and after focal radiation therapy in children with newly diagnosed diffuse intrinsic pontine glioma (DIPG) (stratum A) or with recurrent/progressive HGG (stratum B).

Adenosine: a partially discovered medicinal agent.

Background: A plethora of chemicals exists in human body which can alter physiology in one way or other. Scientists have always been astounded by such abilities of chemicals but as the technology advances, even the chemical which was once expected to be well known changes its status to not really well known. Adenosine is one of the chemicals which is in consonance with the aforementioned statements, although previous articles have covered vast information on role of adenosine in cardiovascular physiology, bacterial pathophysiology and inflammatory diseases.

Surgical Management of Thoracolumbar Spondylodiscitis in End-Stage Renal Disease.

Background: In recent times due to the advancement of haemodialysis techniques, there is increase in the life span of the patients with end-stage renal disease, which tends to increase the risk of complications of bacteraemia due to skin penetration for blood access and leading to propensity for more skeletal and spinal complications. Hence, early diagnosis of spine infection and early initiation of appropriate therapy are important in ensuring successful treatment and preventing further morbidity.

Materials And Methods: The study included 22 males and 12 females who were known case of end-stage renal disease undergoing haemodialysis therapy and diagnosed with spondylodiscitis based on the clinical and radiological signs.

Bond strength of lithium disilicate to polyetheretherketone.

Statement Of Problem: Polyetheretherketone (PEEK) is a high-performance polymer that is increasingly used in dentistry, for example, as a framework for implant-supported fixed complete dentures. One protocol calls for individual lithium disilicate crowns to be cemented on preparation-shaped retentive elements on the framework. However, the flexibility and strength of the bonded system is unclear.

Screening of Health-Associated Oral Bacteria for Anticancer Properties .

While extensive literature exists about the role of oral bacterial pathogens like and in oral squamous cell carcinoma (OSCC), the role of health-associated species has been largely unexplored. In this study, we assessed the effect of , and on proliferation and expression of marker genes (IL-6, TNF-α, MMP3, CD36, CCD1, and NANOG) in OSCC cell lines CAL27, SCC25, and SCC4. was included as a pathogenic control.

Diffuse Sarcoidosis Masquerading as Widespread Malignant Disease: A Rare Case Report and Literature Review.

Sarcoidosis is a multisystem granulomatous disease commonly involving the lungs and mediastinal lymph nodes with the exact etiology being unclear. The simultaneous presence of malignant disease such as breast cancer and sarcoidosis has been reported. Sarcoidosis preceding a diagnosis of malignancy and that occurring years after treatment of malignant disease has been noted in the past.

Artificial Intelligence in Modern Medicine - The Evolving Necessity of the Present and Role in Transforming the Future of Medical Care.

The dexterity of computer systems to resemble and mimic human intelligence is artificial intelligence. Artificial intelligence has reformed the diagnostic and therapeutic precision and competence in various fields of medicine. Artificial intelligence appears to play a bright role in medical diagnosis.

Constrictive Pericarditis: A Commonly Missed Cause of Treatable Diastolic Heart Failure.

Constrictive pericarditis arises as a result of the fibrous thickening of the pericardium due to chronic inflammatory changes from various injuries. Increased pulmonary and systemic venous pressures manifest clinical features of left and right heart failure. Idiopathic or post-viral pericarditis is the most common cause followed by postpericardiotomy, radiation-induced causes.

Renal Artery Stenosis As Etiology of Recurrent Flash Pulmonary Edema and Role of Imaging in Timely Diagnosis and Management.

Renal hypoperfusion from renal artery stenosis (RAS) activates the renin-angiotensin system, which in turn causes volume overload and hypertension. Atherosclerosis and fibromuscular dysplasia are the most common causes of renal artery stenosis. Recurrent flash pulmonary edema, also known as Pickering syndrome, is commonly associated with bilateral renal artery stenosis.

Modified Technique for CAD/CAM Guided Implant Planning in the Presence of Existing Hopeless Teeth.

Immediate placement of dental implants presents many challenges, especially when partial or complete fixed restorations are the intended prosthetic outcome. With modern advancements in CAD/CAM technology, the ease and predictability of such complex cases is vastly improved. However, certain clinical situations remain that preclude the traditional implementation of this controlled approach to implant planning/placement and the current solutions to these problems each impose some level of compromise.

Evaluation of the influence of chronic low-dose radiation on DNA repair gene polymorphisms [, , ] in individuals from normal and high level natural radiation areas of Kerala Coast.

Single Nucleotide Polymorphisms (SNPs) at DNA repair genes are considered as potential biomarkers of radio-sensitivity. The coastal belt of Kerala in south west India has a patchy distribution of monazite in its beach sand that contains Th-232 and its decay products. Thus, radiation levels in this area vary from <1.

Restoration of a partially edentulous patient with combination partial dentures.

Flexible partial removable dental prostheses (PRDP) provide superior aesthetics, durability, improved patient comfort due to softer surface and low elastic modulus, and require less time and expense for fabrication. However, when a flexible PRDP is used to replace several missing teeth, especially when no occlusal rests or vertical stops are present, rotation and sinking of the denture base and resorption of the residual ridge tend to occur. This may result in the concentration of excessive force in the resin clasp, along with clasp deformation or fracture, and compression of the marginal gingiva.

Shark Fin Titanium Hollow Bulb Obturator: A Treatment Concept.

Restoring esthetics and function for patients with maxillectomy defects presents a complex challenge for the clinician. Obturator prostheses are subject to rotational forces during function, allowing movement into the defect. Gaining prosthesis support from endosseous implants can limit the amount of rotation.