The land and sea routes to 2030: a call for greater attention on all small islands in global environmental policy.

Islands have unique vulnerabilities to biodiversity loss and climate change. Current Nationally Determined Contributions under the Paris Agreement are insufficient to avoid the irreversible loss of critical island ecosystems. Existing research, policies, and finance also do not sufficiently address small islands' social-environmental challenges.

Biocompatibility Testing of UV-Curable Polydimethylsiloxane for Human Umbilical Vein Endothelial Cell Culture on-a-Chip.

Polydimethylsiloxane (PDMS) is extensively used to fabricate biocompatible microfluidic systems due to its favorable properties for cell culture. Recently, ultraviolet-curable PDMS (UV-PDMS) has shown potential for enhancing manufacturing processes and final optical quality while retaining the benefits of traditional thermally cured PDMS. This study investigates the biocompatibility of UV-PDMS under static and flow conditions using human umbilical vein endothelial cells (HUVECs).

NeuroEPO plus (NeuralCIM) in mild-to-moderate Alzheimer's clinical syndrome: the ATHENEA randomized clinical trial.

Background: NeuroEPO plus is a recombinant human erythropoietin without erythropoietic activity and shorter plasma half-life due to its low sialic acid content. NeuroEPO plus prevents oxidative damage, neuroinflammation, apoptosis and cognitive deficit in an Alzheimer's disease (AD) models. The aim of this study was to assess efficacy and safety of neuroEPO plus.

Balancing food production with climate change mitigation and biodiversity conservation in the Brazilian Amazon.

Climate change mitigation and biodiversity conservation are two major environmental actions that need to be effectively performed this century, alongside ensuring food supply for a growing global human population. These three issues are highly interlinked through land management systems. Thus, major global food production regions located in biodiversity hotpots and with potential for carbon sequestration face trade-offs between these valuable land-based ecosystem services.

Complex relationships between soybean trade destination and tropical deforestation.

Over the last few years, understanding of the effects of increasingly interconnected global flows of agricultural commodities on coupled human and natural systems has significantly improved. However, many important factors in environmental change that are influenced by these commodity flows are still not well understood. Here, we present an empirical spatial modelling approach to assess how changes in forest cover are influenced by trade destination.

Global gateways as telecoupled human and natural systems: The emerging case of the Bering Strait.

Numerous narrow marine passages around the world serve as essential gateways for the transportation of goods, the movement of people, and the migration of fish and wildlife. These global gateways facilitate human-nature interactions across distant regions. The socioeconomic and environmental interactions among distant coupled human and natural systems affect the sustainability of global gateways in complex ways.

Effects of global shocks on the evolution of an interconnected world.

As the world grows more interconnected through the flows of people, goods, and information, many challenges are becoming more difficult to address since human needs are increasingly being met through global supply chains. Global shocks (e.g.

Socioeconomic and environmental effects of soybean production in metacoupled systems.

Human-environment interactions within and across borders are now more influential than ever, posing unprecedented sustainability challenges. The framework of metacoupling (interactions within and across adjacent and distant coupled human-environment systems) provides a useful tool to evaluate them at diverse temporal and spatial scales. While most metacoupling studies have so far addressed the impacts of distant interactions (telecouplings), few have addressed the complementary and interdependent effects of the interactions within coupled systems (intracouplings) and between adjacent systems (pericouplings).

A global assessment of the impact of individual protected areas on preventing forest loss.

Globally, the number and extent of terrestrial protected areas (PAs) are expanding rapidly. Nonetheless, their impacts on preventing forest loss and the factors influencing the impacts are not well understood, despite the critical roles of forests in biodiversity conservation, provision of ecosystem services, and achievement of the United Nations' Sustainable Development Goals. To address this important knowledge gap, we quantified the impacts of 54,792 PAs worldwide on preventing forest loss from 2000 to 2015, and assessed important landscape and management factors affecting the impacts of PAs.

Foliar absorption coefficient derived from reflectance spectra: A gauge of the efficiency of in situ light-capture by different pigment groups.

The absorption of Photosynthetically Active Radiation (PAR) by different foliar pigments defines the amount of energy available for photosynthesis and also the need for photoprotection. Both characteristics reveal essential information about productivity, development, and stress acclimation of plants. Here we present an approach for the estimation of the efficiency by three foliar pigment groups (chlorophylls, carotenoids, and anthocyanins) at capturing light, via the absorption coefficient derived from leaf reflectance spectra.

Interactive spatial scale effects on species distribution modeling: The case of the giant panda.

Research has shown that varying spatial scale through the selection of the total extent of investigation and the grain size of environmental predictor variables has effects on species distribution model (SDM) results and accuracy, but there has been minimal investigation into the interactive effects of extent and grain. To do this, we used a consistently sampled range-wide dataset of giant panda occurrence across southwest China and modeled their habitat and distribution at 4 extents and 7 grain sizes. We found that increasing grain size reduced model accuracy at the smallest extent, but that increasing extent negated this effect.

Effectiveness of China's protected areas in reducing deforestation.

Protected areas (PAs) are considered a cornerstone of biodiversity conservation, and the number and extent of PAs are expanding rapidly worldwide. While designating more land as PAs is important, concerns about the degree to which existing PAs are effective in meeting conservation goals are growing. Unfortunately, conservation effectiveness of PAs and its underlying determinants are often unclear across large spatial scales.

Mixed Th2 and non-Th2 inflammatory pattern in the asthma-COPD overlap: a network approach.

Introduction: The asthma-chronic obstructive pulmonary disease (COPD) overlap (ACO) is a clinical condition that combines features of those two diseases, and that is difficult to define due to the lack of understanding of the underlying mechanisms. Determining systemic mediators may help clarify the nature of inflammation in patients with ACO.

Objectives: We aimed at investigating the role and interaction of common markers of systemic inflammation (IL-6, IL-8, and tumor necrosis factor-α), Th2-related markers (periostin, IL-5, and IL-13), and IL-17 in asthma, COPD, and ACO.

Uncertainty of future projections of species distributions in mountainous regions.

Multiple factors introduce uncertainty into projections of species distributions under climate change. The uncertainty introduced by the choice of baseline climate information used to calibrate a species distribution model and to downscale global climate model (GCM) simulations to a finer spatial resolution is a particular concern for mountainous regions, as the spatial resolution of climate observing networks is often insufficient to detect the steep climatic gradients in these areas. Using the maximum entropy (MaxEnt) modeling framework together with occurrence data on 21 understory bamboo species distributed across the mountainous geographic range of the Giant Panda, we examined the differences in projected species distributions obtained from two contrasting sources of baseline climate information, one derived from spatial interpolation of coarse-scale station observations and the other derived from fine-spatial resolution satellite measurements.

Reassessing the conservation status of the giant panda using remote sensing.

The conservation status of the iconic giant panda is a barometer of global conservation efforts. The IUCN Red List has downgraded the panda's extinction risk from "endangered" to "vulnerable". Newly obtained, detailed GIS and remotely sensed data applied consistently over the last four decades show that panda habitat covered less area and was more fragmented in 2013 than in 1988 when the species was listed as endangered.

Habitat Use and Selection by Giant Pandas.

Animals make choices about where to spend their time in complex and dynamic landscapes, choices that reveal information about their biology that in turn can be used to guide their conservation. Using GPS collars, we conducted a novel individual-based analysis of habitat use and selection by the elusive and endangered giant pandas (Ailuropoda melanoleuca). We constructed spatial autoregressive resource utilization functions (RUF) to model the relationship between the pandas' utilization distributions and various habitat characteristics over a continuous space across seasons.

Efficiency of chlorophyll in gross primary productivity: A proof of concept and application in crops.

One of the main factors affecting vegetation productivity is absorbed light, which is largely governed by chlorophyll. In this paper, we introduce the concept of chlorophyll efficiency, representing the amount of gross primary production per unit of canopy chlorophyll content (Chl) and incident PAR. We analyzed chlorophyll efficiency in two contrasting crops (soybean and maize).

Effects of conservation policy on China's forest recovery.

Forest loss is one of the most pervasive land surface transformations on Earth, with drastic effects on global climate, ecosystems, and human well-being. As part of biodiversity conservation and climate change mitigation efforts, many countries, including China, have been implementing large-scale policies to conserve and restore forests. However, little is known about the effectiveness of these policies, and information on China's forest dynamics at the national level has mainly relied on official statistics.

Effects of payments for ecosystem services on wildlife habitat recovery.

Conflicts between local people's livelihoods and conservation have led to many unsuccessful conservation efforts and have stimulated debates on policies that might simultaneously promote sustainable management of protected areas and improve the living conditions of local people. Many government-sponsored payments-for-ecosystem-services (PES) schemes have been implemented around the world. However, few empirical assessments of their effectiveness have been conducted, and even fewer assessments have directly measured their effects on ecosystem services.

Effects of Conservation Policies on Forest Cover Change in Giant Panda Habitat Regions, China.

After long periods of deforestation, forest transition has occurred globally, but the causes of forest transition in different countries are highly variable. Conservation policies may play important roles in facilitating forest transition around the world, including China. To restore forests and protect the remaining natural forests, the Chinese government initiated two nationwide conservation policies in the late 1990s -- the Natural Forest Conservation Program (NFCP) and the Grain-To-Green Program (GTGP).

Nonlinear effects of group size on collective action and resource outcomes.

For decades, scholars have been trying to determine whether small or large groups are more likely to cooperate for collective action and successfully manage common-pool resources. Using data gathered from the Wolong Nature Reserve since 1995, we examined the effects of group size (i.e.

Performance and prospects of payments for ecosystem services programs: evidence from China.

Systematic evaluation of the environmental and socioeconomic effects of Payments for Ecosystem Services (PES) programs is crucial for guiding policy design and implementation. We evaluated the performance of the Natural Forest Conservation Program (NFCP), a national PES program of China, in the Wolong Nature Reserve for giant pandas. The environmental effects of the NFCP were evaluated through a historical trend (1965-2001) analysis of forest cover to estimate a counter-factual (i.