Publications by authors named "Vimalraj Vijayakumar"
High-flow nasal oxygen in infants and children for early respiratory management of pneumonia-induced acute hypoxemic respiratory failure: the CENTURI randomized clinical trial.
Intensive Care Med Paediatr Neonatal
April 2024
Article Synopsis
- This study compared the effectiveness of high-flow nasal cannula (HFNC) oxygen therapy versus low-flow oxygen support (LFOS) in children under 5 with acute hypoxemic respiratory failure from severe pneumonia in low-middle-income countries.
- An open-label randomized trial involved 244 children, analyzing the failure rates of treatment within 72 hours, where HFNC displayed a significantly lower failure rate (7.3%) compared to LFOS (20%).
- The conclusion indicated that early use of HFNC resulted in better outcomes and fewer necessary intubations, highlighting its potential as a preferred treatment for young children with this condition.
Diabetic ketoacidosis (DKA) was observed in a 12-year-old female child recently diagnosed with type 1 diabetes mellitus. A rise in triglyceride (TG) levels accompanied this. High TG levels were suspected due to the lipemic appearance of the serum.
View Article and Find Full Text PDFObjectives: To determine whether levetiracetam is an alternative to fosphenytoin to control Benzodiazepine Refractory Status Epilepticus (BRSE) in pediatric population and also to compare the acute drug related side-effects and ventilation requirement among the both arms of anti-epileptic drug therapy.
Methods: All consecutive children admitted with BRSE were randomized to group A, who received fosphenytoin at 20 mg/kg phenytoin equivalents (PE) dose and group B who received levetiracetam at 40 mg/kg over 10 min. Time to terminate seizure (response latency) was measured.