Using HScore for Evaluation of Hemophagocytosis in Multisystem Inflammatory Syndrome Associated with COVID-19 in Children.

Hemophagocytic syndrome is a key point in the pathogenesis of severe forms of multisystem inflammatory syndrome associated with COVID-19 in children (MIS-C). The factors associated with hemophagocytosis in patients with MIS-C were assessed in the present study of 94 boys and 64 girls ranging in age from 4 months to 17 years, each of whose HScore was calculated. In accordance with a previous analysis, patients with HScore ≤ 91 ( = 79) and HScore > 91 ( = 79) were compared.

[FIRES Syndrome in a Preschool Child].

Severe epileptic syndromes of childhood are an urgent problem for pediatric neurologists and neuroresuscitators. The article presents a clinical observation of FIRES syndrome in a pediatric patient, which is a form of severe drug-resistant epilepsy in children of preschool and school age, the development of which is caused by hyperthermia, probably associated with herpesvirus (human herpesvirus type 6) infection. The features of the progressive course and the difficulties of diagnostic search are reflected.

Heart Involvement in Multisystem Inflammatory Syndrome, Associated With COVID-19 in Children: The Retrospective Multicenter Cohort Data.

Objectives: Heart involvement in multisystem inflammatory syndrome associated with COVID-19 in children (MIS-C) is a new challenging problem, requiring fast and reliable diagnostics and appropriate treatment. The aim of this study is to describe heart involvement in patients with MIS-C.

Study Design: In this retrospective, multicenter cohort study, data of 122 patients were included.

[SEVERE INFECTIOUS DISEASE AS A PREDICTOR OF CRITICAL ILLNESS ENCEPHALOPATHY IN CHILDREN (CLINICAL CASE)].

In childhood, infectious diseases, as a rule, are generalized in nature with the development of urgent or critical conditions that require the transfer of the child to mechanical ventilation. A child's stay on mechanical ventilation, on the one hand, is vital, on the other hand, it is a factor that threatens the development of acute encephalopathy, mechanical ventilation associated pneumonia, polyneuropathy and myopathy of critical conditions. According to the authors, the incidence of critical encephalopathy in patients with generalized infectious diseases who are on mechanical ventilation is 75%, and in the long-term (after 1 year) outcome in convalescents, the frequency of neurological deficit reaches 33%.

[Problems of differential diagnosis of acute symptomatic infectious seizures and epilepsy in children].

Viral encephalitis, its complications and the newly diagnosed epilepsy in children require a complex approach to the differential diagnosis using laboratory and instrumental examinations. Possibilities of MRI in the differential diagnosis of seizures in children and in detection of ischemic-hypoxic and metabolic disorders in the suspected epileptic focus are demonstrated in the clinical observation.

[Possibilities for optimizing the pathogenetic therapy of purulent meningitis in children].

Aim: To assess an effect of the combined use of Cytoflavin and Sulodexide on the course and outcomes of purulent meningitis in children.

Material And Methods: Fifty children with purulent meningitis, aged from 5 to 17 years 11 month, were studied. Thirty patients of the treatment group (n=30; mean age 6,8 ± 2,2 years) received Cytoflavin (0,6 mcg/kg once a day) during 5 days with the following treatment with Sulodexide (250 LSU/day in children 5-12 years, 500 LSU/day in children above 12 years).

[POLYNEUROPATHY IN CRITICALLY ILL CHILDREN WITH INFECTIOUS DISEASES].

14 pediatric critically ill patients with various infectious pathologies were assessed. Electroneuromyography was carried out in all patients. Polyneuropathy of critical states were revealed in 10 children.

[Laboratory evaluation of the severity of intoxication syndrome in children with bacterial infections].

For the laboratory evaluation of the severity of intoxication syndrome, the spectral characteristics of low and median molecular weight substances (LMMWS) were studied in the plasma and red blood cells of 129 children with bacterial infections, among whom there were 76 children with acute intestinal infections (Flexner's dysentery, Sonne dysentery, and salmonellosis) and 53 children with bacterial purulent meningitis of hemophilic and meningococcal etiology. In the acute period, all the examinees were found to have considerable qualitative and quantitative distinctions of blood spectrograms from the normal values. There was an association of the spectral characteristics of blood LMMWS with the nosological entity, etiology and stage of disease, and the severity of intoxication syndrome.